Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.

Dendritic cells (DC) represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte (CTL) responses against viral infections. Targeting antigens (Ag) to receptors on DCs is a promising strategy to enhance antitumor and antiviral immune responses induced by DCs. Here,...

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Autores principales:	Asim Ejaz, Christoph G Ammann, Roland Werner, Georg Huber, Verena Oberhauser, Susanne Hörl, Simone Schimmer, Ulf Dittmer, Dorothee von Laer, Heribert Stoiber, Zoltán Bánki
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c06034d027c4a84bca8dc487c3ae35e
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spelling	oai:doaj.org-article:9c06034d027c4a84bca8dc487c3ae35e2021-11-18T07:05:23ZTargeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.1932-620310.1371/journal.pone.0045102https://doaj.org/article/9c06034d027c4a84bca8dc487c3ae35e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028784/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Dendritic cells (DC) represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte (CTL) responses against viral infections. Targeting antigens (Ag) to receptors on DCs is a promising strategy to enhance antitumor and antiviral immune responses induced by DCs. Here, we investigated the potential of CD11c-specific single-chain fragments (scFv) fused to an immunodominant peptide of Friend retrovirus for induction of virus-specific T cell responses by DCs. In vitro CD11c-specific scFv selectively targeted viral antigens to DCs and thereby significantly improved the activation of virus-specific T cells. In vaccination experiments DCs loaded with viral Ag targeted to CD11c provided improved rejection of FV-derived tumors and efficiently primed virus-specific CTL responses after virus challenge. Since the induction of strong virus-specific T cell responses is critical in viral infections, CD11c targeted protein vaccines might provide means to enhance the cellular immune response to prophylactic or therapeutic levels.Asim EjazChristoph G AmmannRoland WernerGeorg HuberVerena OberhauserSusanne HörlSimone SchimmerUlf DittmerDorothee von LaerHeribert StoiberZoltán BánkiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45102 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asim Ejaz Christoph G Ammann Roland Werner Georg Huber Verena Oberhauser Susanne Hörl Simone Schimmer Ulf Dittmer Dorothee von Laer Heribert Stoiber Zoltán Bánki Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
description	Dendritic cells (DC) represent the most potent antigen presenting cells and induce efficient cytotoxic T lymphocyte (CTL) responses against viral infections. Targeting antigens (Ag) to receptors on DCs is a promising strategy to enhance antitumor and antiviral immune responses induced by DCs. Here, we investigated the potential of CD11c-specific single-chain fragments (scFv) fused to an immunodominant peptide of Friend retrovirus for induction of virus-specific T cell responses by DCs. In vitro CD11c-specific scFv selectively targeted viral antigens to DCs and thereby significantly improved the activation of virus-specific T cells. In vaccination experiments DCs loaded with viral Ag targeted to CD11c provided improved rejection of FV-derived tumors and efficiently primed virus-specific CTL responses after virus challenge. Since the induction of strong virus-specific T cell responses is critical in viral infections, CD11c targeted protein vaccines might provide means to enhance the cellular immune response to prophylactic or therapeutic levels.
format	article
author	Asim Ejaz Christoph G Ammann Roland Werner Georg Huber Verena Oberhauser Susanne Hörl Simone Schimmer Ulf Dittmer Dorothee von Laer Heribert Stoiber Zoltán Bánki
author_facet	Asim Ejaz Christoph G Ammann Roland Werner Georg Huber Verena Oberhauser Susanne Hörl Simone Schimmer Ulf Dittmer Dorothee von Laer Heribert Stoiber Zoltán Bánki
author_sort	Asim Ejaz
title	Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
title_short	Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
title_full	Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
title_fullStr	Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
title_full_unstemmed	Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.
title_sort	targeting viral antigens to cd11c on dendritic cells induces retrovirus-specific t cell responses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9c06034d027c4a84bca8dc487c3ae35e
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Targeting viral antigens to CD11c on dendritic cells induces retrovirus-specific T cell responses.

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