Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells

Introduction. Myrtus communis, Aristolochia longa, and Calycotome spinosa are medicinal plants frequently used in Algeria. Some plants can cause a fragility of the erythrocyte membrane and lead to hemolysis. Therefore, we aimed to study the cytotoxicity of aqueous extracts from the aerial part of th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leila Gadouche, Azdinia Zidane, Khayra Zerrouki, Karima Azouni, Saadia Bouinoune
Formato:	article
Lenguaje:	EN
Publicado:	Kemerovo State University 2021
Materias:	myrtus communis aristolochia longa calycotome spinosa folk medicine phenolic compounds alkaloids hemoglobin cell toxicity hemolytic activity Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/9c072a3eb4ab4c22852a56292dfa1684
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c072a3eb4ab4c22852a56292dfa1684
record_format	dspace
spelling	oai:doaj.org-article:9c072a3eb4ab4c22852a56292dfa16842021-11-19T04:02:56ZCytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells2308-40572310-959910.21603/2308-4057-2021-2-379-386https://doaj.org/article/9c072a3eb4ab4c22852a56292dfa16842021-11-01T00:00:00Zhttp://jfrm.ru/en/issues/1879/1955/https://doaj.org/toc/2308-4057https://doaj.org/toc/2310-9599Introduction. Myrtus communis, Aristolochia longa, and Calycotome spinosa are medicinal plants frequently used in Algeria. Some plants can cause a fragility of the erythrocyte membrane and lead to hemolysis. Therefore, we aimed to study the cytotoxicity of aqueous extracts from the aerial part of these species against red blood cells. Study objects and methods. The hemolytic effect was determined spectrophotometrically by incubating an erythrocyte solution with different concentrations of the aqueous extracts (25, 50, 100, and 200 mg/mL) at 37°C during one hour. In addition, we performed phytochemical screening and measured the contents of polyphenols and flavonoids. Results and discussion. After one hour of incubation of human red blood cells with the aqueous extracts at different concentrations, the hemolysis percentage showed a significant leak of hemoglobin with A. longa (68.75 ± 6.11%; 200 mg/mL), the most toxic extract followed by C. spinosa (34.86 ± 5.06%; 200 mg/mL). In contrast, M. communis showed very low cytotoxicity (20.13 ± 3.11%; 200 mg/mL). Conclusion. These plants are sources of a wide range of bioactive compounds but their use in traditional medicine must be adapted to avoid any toxic effect.Leila GadoucheAzdinia ZidaneKhayra ZerroukiKarima AzouniSaadia BouinouneKemerovo State Universityarticlemyrtus communisaristolochia longacalycotome spinosafolk medicinephenolic compoundsalkaloidshemoglobincell toxicityhemolytic activityFood processing and manufactureTP368-456ENFoods and Raw Materials, Vol 9, Iss 2, Pp 379-386 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myrtus communis aristolochia longa calycotome spinosa folk medicine phenolic compounds alkaloids hemoglobin cell toxicity hemolytic activity Food processing and manufacture TP368-456
spellingShingle	myrtus communis aristolochia longa calycotome spinosa folk medicine phenolic compounds alkaloids hemoglobin cell toxicity hemolytic activity Food processing and manufacture TP368-456 Leila Gadouche Azdinia Zidane Khayra Zerrouki Karima Azouni Saadia Bouinoune Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
description	Introduction. Myrtus communis, Aristolochia longa, and Calycotome spinosa are medicinal plants frequently used in Algeria. Some plants can cause a fragility of the erythrocyte membrane and lead to hemolysis. Therefore, we aimed to study the cytotoxicity of aqueous extracts from the aerial part of these species against red blood cells. Study objects and methods. The hemolytic effect was determined spectrophotometrically by incubating an erythrocyte solution with different concentrations of the aqueous extracts (25, 50, 100, and 200 mg/mL) at 37°C during one hour. In addition, we performed phytochemical screening and measured the contents of polyphenols and flavonoids. Results and discussion. After one hour of incubation of human red blood cells with the aqueous extracts at different concentrations, the hemolysis percentage showed a significant leak of hemoglobin with A. longa (68.75 ± 6.11%; 200 mg/mL), the most toxic extract followed by C. spinosa (34.86 ± 5.06%; 200 mg/mL). In contrast, M. communis showed very low cytotoxicity (20.13 ± 3.11%; 200 mg/mL). Conclusion. These plants are sources of a wide range of bioactive compounds but their use in traditional medicine must be adapted to avoid any toxic effect.
format	article
author	Leila Gadouche Azdinia Zidane Khayra Zerrouki Karima Azouni Saadia Bouinoune
author_facet	Leila Gadouche Azdinia Zidane Khayra Zerrouki Karima Azouni Saadia Bouinoune
author_sort	Leila Gadouche
title	Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
title_short	Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
title_full	Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
title_fullStr	Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
title_full_unstemmed	Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells
title_sort	cytotoxic effect of myrtus communis, aristolochia longa, and calycotome spinosa on human erythrocyte cells
publisher	Kemerovo State University
publishDate	2021
url	https://doaj.org/article/9c072a3eb4ab4c22852a56292dfa1684
work_keys_str_mv	AT leilagadouche cytotoxiceffectofmyrtuscommunisaristolochialongaandcalycotomespinosaonhumanerythrocytecells AT azdiniazidane cytotoxiceffectofmyrtuscommunisaristolochialongaandcalycotomespinosaonhumanerythrocytecells AT khayrazerrouki cytotoxiceffectofmyrtuscommunisaristolochialongaandcalycotomespinosaonhumanerythrocytecells AT karimaazouni cytotoxiceffectofmyrtuscommunisaristolochialongaandcalycotomespinosaonhumanerythrocytecells AT saadiabouinoune cytotoxiceffectofmyrtuscommunisaristolochialongaandcalycotomespinosaonhumanerythrocytecells
_version_	1718420509560930304

Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells

Ejemplares similares