PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair

PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.

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Autores principales:	Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
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spelling	oai:doaj.org-article:9c0730c851de40b5b3372bd7dc7822b12021-12-02T15:34:28ZPAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair10.1038/s41467-018-06127-y2041-1723https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b12018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06127-yhttps://doaj.org/toc/2041-1723PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.Andrew CraxtonDeeksha MunnurRebekah Jukes-JonesGeorge SkalkaClaudia LanglaisKelvin CainMichal MalewiczNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew Craxton Deeksha Munnur Rebekah Jukes-Jones George Skalka Claudia Langlais Kelvin Cain Michal Malewicz PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
description	PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.
format	article
author	Andrew Craxton Deeksha Munnur Rebekah Jukes-Jones George Skalka Claudia Langlais Kelvin Cain Michal Malewicz
author_facet	Andrew Craxton Deeksha Munnur Rebekah Jukes-Jones George Skalka Claudia Langlais Kelvin Cain Michal Malewicz
author_sort	Andrew Craxton
title	PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
title_short	PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
title_full	PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
title_fullStr	PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
title_full_unstemmed	PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair
title_sort	paxx and its paralogs synergistically direct dna polymerase λ activity in dna repair
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
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PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair

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