Silencing of TGFβ signalling in microglia results in impaired homeostasis

While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tanja Zöller, Artur Schneider, Christian Kleimeyer, Takahiro Masuda, Phani Sankar Potru, Dietmar Pfeifer, Thomas Blank, Marco Prinz, Björn Spittau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c07823b43e44ed589f74142507a83ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c07823b43e44ed589f74142507a83ca
record_format	dspace
spelling	oai:doaj.org-article:9c07823b43e44ed589f74142507a83ca2021-12-02T14:41:05ZSilencing of TGFβ signalling in microglia results in impaired homeostasis10.1038/s41467-018-06224-y2041-1723https://doaj.org/article/9c07823b43e44ed589f74142507a83ca2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06224-yhttps://doaj.org/toc/2041-1723While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia.Tanja ZöllerArtur SchneiderChristian KleimeyerTakahiro MasudaPhani Sankar PotruDietmar PfeiferThomas BlankMarco PrinzBjörn SpittauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau Silencing of TGFβ signalling in microglia results in impaired homeostasis
description	While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia.
format	article
author	Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau
author_facet	Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau
author_sort	Tanja Zöller
title	Silencing of TGFβ signalling in microglia results in impaired homeostasis
title_short	Silencing of TGFβ signalling in microglia results in impaired homeostasis
title_full	Silencing of TGFβ signalling in microglia results in impaired homeostasis
title_fullStr	Silencing of TGFβ signalling in microglia results in impaired homeostasis
title_full_unstemmed	Silencing of TGFβ signalling in microglia results in impaired homeostasis
title_sort	silencing of tgfβ signalling in microglia results in impaired homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c07823b43e44ed589f74142507a83ca
work_keys_str_mv	AT tanjazoller silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT arturschneider silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT christiankleimeyer silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT takahiromasuda silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT phanisankarpotru silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT dietmarpfeifer silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT thomasblank silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT marcoprinz silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis AT bjornspittau silencingoftgfbsignallinginmicrogliaresultsinimpairedhomeostasis
_version_	1718390008639913984

Silencing of TGFβ signalling in microglia results in impaired homeostasis

Ejemplares similares