KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.

Molecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we identify Mamu-A1*00201 (Mamu-A*02), a common MHC class I molecule in the rhesus...

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Autores principales: Arnaud D Colantonio, Benjamin N Bimber, William J Neidermyer, R Keith Reeves, Galit Alter, Marcus Altfeld, R Paul Johnson, Mary Carrington, David H O'Connor, David T Evans
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/9c08f1e1496f4f9981d0ba1da7d7aa98
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