A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.

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Autores principales: Chao Sheng, Johannes Jungverdorben, Hendrik Wiethoff, Qiong Lin, Lea J. Flitsch, Daniela Eckert, Matthias Hebisch, Julia Fischer, Jaideep Kesavan, Beatrice Weykopf, Linda Schneider, Dominik Holtkamp, Heinz Beck, Andreas Till, Ullrich Wüllner, Michael J. Ziller, Wolfgang Wagner, Michael Peitz, Oliver Brüstle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9c09e47ee2e347998c07481693058095
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spelling oai:doaj.org-article:9c09e47ee2e347998c074816930580952021-12-02T15:34:17ZA stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation10.1038/s41467-018-06398-52041-1723https://doaj.org/article/9c09e47ee2e347998c074816930580952018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06398-5https://doaj.org/toc/2041-1723Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.Chao ShengJohannes JungverdorbenHendrik WiethoffQiong LinLea J. FlitschDaniela EckertMatthias HebischJulia FischerJaideep KesavanBeatrice WeykopfLinda SchneiderDominik HoltkampHeinz BeckAndreas TillUllrich WüllnerMichael J. ZillerWolfgang WagnerMichael PeitzOliver BrüstleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chao Sheng
Johannes Jungverdorben
Hendrik Wiethoff
Qiong Lin
Lea J. Flitsch
Daniela Eckert
Matthias Hebisch
Julia Fischer
Jaideep Kesavan
Beatrice Weykopf
Linda Schneider
Dominik Holtkamp
Heinz Beck
Andreas Till
Ullrich Wüllner
Michael J. Ziller
Wolfgang Wagner
Michael Peitz
Oliver Brüstle
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
description Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.
format article
author Chao Sheng
Johannes Jungverdorben
Hendrik Wiethoff
Qiong Lin
Lea J. Flitsch
Daniela Eckert
Matthias Hebisch
Julia Fischer
Jaideep Kesavan
Beatrice Weykopf
Linda Schneider
Dominik Holtkamp
Heinz Beck
Andreas Till
Ullrich Wüllner
Michael J. Ziller
Wolfgang Wagner
Michael Peitz
Oliver Brüstle
author_facet Chao Sheng
Johannes Jungverdorben
Hendrik Wiethoff
Qiong Lin
Lea J. Flitsch
Daniela Eckert
Matthias Hebisch
Julia Fischer
Jaideep Kesavan
Beatrice Weykopf
Linda Schneider
Dominik Holtkamp
Heinz Beck
Andreas Till
Ullrich Wüllner
Michael J. Ziller
Wolfgang Wagner
Michael Peitz
Oliver Brüstle
author_sort Chao Sheng
title A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
title_short A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
title_full A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
title_fullStr A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
title_full_unstemmed A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
title_sort stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9c09e47ee2e347998c07481693058095
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