Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal r...

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Autores principales:	Dmitry Shungin, Simon Haworth, Kimon Divaris, Cary S. Agler, Yoichiro Kamatani, Myoung Keun Lee, Kelsey Grinde, George Hindy, Viivi Alaraudanjoki, Paula Pesonen, Alexander Teumer, Birte Holtfreter, Saori Sakaue, Jun Hirata, Yau-Hua Yu, Paul M. Ridker, Franco Giulianini, Daniel I. Chasman, Patrik K. E. Magnusson, Takeaki Sudo, Yukinori Okada, Uwe Völker, Thomas Kocher, Vuokko Anttonen, Marja-Liisa Laitala, Marju Orho-Melander, Tamar Sofer, John R. Shaffer, Alexandre Vieira, Mary L. Marazita, Michiaki Kubo, Yasushi Furuichi, Kari E. North, Steve Offenbacher, Erik Ingelsson, Paul W. Franks, Nicholas J. Timpson, Ingegerd Johansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c0e19f3136944e4b0b2db9b41f36485
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spelling	oai:doaj.org-article:9c0e19f3136944e4b0b2db9b41f364852021-12-02T15:35:02ZGenome-wide analysis of dental caries and periodontitis combining clinical and self-reported data10.1038/s41467-019-10630-12041-1723https://doaj.org/article/9c0e19f3136944e4b0b2db9b41f364852019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10630-1https://doaj.org/toc/2041-1723Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.Dmitry ShunginSimon HaworthKimon DivarisCary S. AglerYoichiro KamataniMyoung Keun LeeKelsey GrindeGeorge HindyViivi AlaraudanjokiPaula PesonenAlexander TeumerBirte HoltfreterSaori SakaueJun HirataYau-Hua YuPaul M. RidkerFranco GiulianiniDaniel I. ChasmanPatrik K. E. MagnussonTakeaki SudoYukinori OkadaUwe VölkerThomas KocherVuokko AnttonenMarja-Liisa LaitalaMarju Orho-MelanderTamar SoferJohn R. ShafferAlexandre VieiraMary L. MarazitaMichiaki KuboYasushi FuruichiKari E. NorthSteve OffenbacherErik IngelssonPaul W. FranksNicholas J. TimpsonIngegerd JohanssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
description	Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.
format	article
author	Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson
author_facet	Dmitry Shungin Simon Haworth Kimon Divaris Cary S. Agler Yoichiro Kamatani Myoung Keun Lee Kelsey Grinde George Hindy Viivi Alaraudanjoki Paula Pesonen Alexander Teumer Birte Holtfreter Saori Sakaue Jun Hirata Yau-Hua Yu Paul M. Ridker Franco Giulianini Daniel I. Chasman Patrik K. E. Magnusson Takeaki Sudo Yukinori Okada Uwe Völker Thomas Kocher Vuokko Anttonen Marja-Liisa Laitala Marju Orho-Melander Tamar Sofer John R. Shaffer Alexandre Vieira Mary L. Marazita Michiaki Kubo Yasushi Furuichi Kari E. North Steve Offenbacher Erik Ingelsson Paul W. Franks Nicholas J. Timpson Ingegerd Johansson
author_sort	Dmitry Shungin
title	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_short	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_full	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_fullStr	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_full_unstemmed	Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
title_sort	genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c0e19f3136944e4b0b2db9b41f36485
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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

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