Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy

Some chemotherapeutic drugs, such as doxorubicin, induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces the expression of PD-L1 in cancer cells and enhances doxorubicin-i...

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Autores principales:	Jing Liu, Zhihao Zhao, Nasha Qiu, Quan Zhou, Guowei Wang, Haiping Jiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c13235dc1e945df90f7c6920d76d06e
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spelling	oai:doaj.org-article:9c13235dc1e945df90f7c6920d76d06e2021-12-02T17:33:33ZCo-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy10.1038/s41467-021-22407-62041-1723https://doaj.org/article/9c13235dc1e945df90f7c6920d76d06e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22407-6https://doaj.org/toc/2041-1723Some chemotherapeutic drugs, such as doxorubicin, induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces the expression of PD-L1 in cancer cells and enhances doxorubicin-induced ICD, promoting T cell infiltration and reducing tumor growth in preclinical models.Jing LiuZhihao ZhaoNasha QiuQuan ZhouGuowei WangHaiping JiangYing PiaoZhuxian ZhouJianbin TangYouqing ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Liu Zhihao Zhao Nasha Qiu Quan Zhou Guowei Wang Haiping Jiang Ying Piao Zhuxian Zhou Jianbin Tang Youqing Shen Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
description	Some chemotherapeutic drugs, such as doxorubicin, induce immunogenic cell death (ICD) and promote anti-tumor immune responses. Here the authors report that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces the expression of PD-L1 in cancer cells and enhances doxorubicin-induced ICD, promoting T cell infiltration and reducing tumor growth in preclinical models.
format	article
author	Jing Liu Zhihao Zhao Nasha Qiu Quan Zhou Guowei Wang Haiping Jiang Ying Piao Zhuxian Zhou Jianbin Tang Youqing Shen
author_facet	Jing Liu Zhihao Zhao Nasha Qiu Quan Zhou Guowei Wang Haiping Jiang Ying Piao Zhuxian Zhou Jianbin Tang Youqing Shen
author_sort	Jing Liu
title	Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
title_short	Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
title_full	Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
title_fullStr	Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
title_full_unstemmed	Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
title_sort	co-delivery of iox1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c13235dc1e945df90f7c6920d76d06e
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Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy

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