Self-organized formation of developing appendages from murine pluripotent stem cells

Organoid technology has been applied to model many types of organs in vitro, although structures containing multiple germ layers, such as limb buds, have not been generated. Here, the authors induce limb bud-like tissues from mouse ESCs that can be functionally integrated after transplantation.

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Autores principales:	Shunsuke Mori, Eriko Sakakura, Yuji Tsunekawa, Masaya Hagiwara, Takayuki Suzuki, Mototsugu Eiraku
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c137614642140f68597ed32179afbb5
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spelling	oai:doaj.org-article:9c137614642140f68597ed32179afbb52021-12-02T16:58:05ZSelf-organized formation of developing appendages from murine pluripotent stem cells10.1038/s41467-019-11702-y2041-1723https://doaj.org/article/9c137614642140f68597ed32179afbb52019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11702-yhttps://doaj.org/toc/2041-1723Organoid technology has been applied to model many types of organs in vitro, although structures containing multiple germ layers, such as limb buds, have not been generated. Here, the authors induce limb bud-like tissues from mouse ESCs that can be functionally integrated after transplantation.Shunsuke MoriEriko SakakuraYuji TsunekawaMasaya HagiwaraTakayuki SuzukiMototsugu EirakuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shunsuke Mori Eriko Sakakura Yuji Tsunekawa Masaya Hagiwara Takayuki Suzuki Mototsugu Eiraku Self-organized formation of developing appendages from murine pluripotent stem cells
description	Organoid technology has been applied to model many types of organs in vitro, although structures containing multiple germ layers, such as limb buds, have not been generated. Here, the authors induce limb bud-like tissues from mouse ESCs that can be functionally integrated after transplantation.
format	article
author	Shunsuke Mori Eriko Sakakura Yuji Tsunekawa Masaya Hagiwara Takayuki Suzuki Mototsugu Eiraku
author_facet	Shunsuke Mori Eriko Sakakura Yuji Tsunekawa Masaya Hagiwara Takayuki Suzuki Mototsugu Eiraku
author_sort	Shunsuke Mori
title	Self-organized formation of developing appendages from murine pluripotent stem cells
title_short	Self-organized formation of developing appendages from murine pluripotent stem cells
title_full	Self-organized formation of developing appendages from murine pluripotent stem cells
title_fullStr	Self-organized formation of developing appendages from murine pluripotent stem cells
title_full_unstemmed	Self-organized formation of developing appendages from murine pluripotent stem cells
title_sort	self-organized formation of developing appendages from murine pluripotent stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c137614642140f68597ed32179afbb5
work_keys_str_mv	AT shunsukemori selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells AT erikosakakura selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells AT yujitsunekawa selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells AT masayahagiwara selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells AT takayukisuzuki selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells AT mototsugueiraku selforganizedformationofdevelopingappendagesfrommurinepluripotentstemcells
_version_	1718382404500979712

Self-organized formation of developing appendages from murine pluripotent stem cells

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