CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.

<h4>Background</h4>During the inflammatory process, chemokine CXCL8 plays a pivotal role in recruitment of human neutrophilic granulocytes. A diversity of sequences similar to CXCL8 was reported in fish, but their evolutionary relationships and functional homology with their human homolo...

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Autores principales:	Lieke M van der Aa, Magdalena Chadzinska, Edwin Tijhaar, Pierre Boudinot, B M Lidy Verburg-van Kemenade
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c13f7be0750438d8a7950b864931ab2
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spelling	oai:doaj.org-article:9c13f7be0750438d8a7950b864931ab22021-11-18T06:35:41ZCXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.1932-620310.1371/journal.pone.0012384https://doaj.org/article/9c13f7be0750438d8a7950b864931ab22010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20865040/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>During the inflammatory process, chemokine CXCL8 plays a pivotal role in recruitment of human neutrophilic granulocytes. A diversity of sequences similar to CXCL8 was reported in fish, but their evolutionary relationships and functional homology with their human homolog remain unclear.<h4>Principal findings</h4>We screened fish genomes to seek for sequences related to CXCL8. A first lineage was retrieved in all teleosts, while a second CXCL8 lineage was found in zebrafish and carp only. An early inflammatory function for both lineages was indicated by several lines of evidence. The induction of carp CXCL8s, CXCb, and CXC receptor-1 and -2 was analyzed after in vitro stimulation of leukocyte subpopulations and in two in vivo inflammation models. Recombinant proteins of carp CXCL8 proteins were produced and showed significant chemotactic activity for carp leukocytes.<h4>Conclusions</h4>While both carp CXCL8s appear to be functional homologs of mammalian CXCL8, their different induction requirements and kinetics evoke a gene-specific sub-functionalization.Lieke M van der AaMagdalena ChadzinskaEdwin TijhaarPierre BoudinotB M Lidy Verburg-van KemenadePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12384 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lieke M van der Aa Magdalena Chadzinska Edwin Tijhaar Pierre Boudinot B M Lidy Verburg-van Kemenade CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
description	<h4>Background</h4>During the inflammatory process, chemokine CXCL8 plays a pivotal role in recruitment of human neutrophilic granulocytes. A diversity of sequences similar to CXCL8 was reported in fish, but their evolutionary relationships and functional homology with their human homolog remain unclear.<h4>Principal findings</h4>We screened fish genomes to seek for sequences related to CXCL8. A first lineage was retrieved in all teleosts, while a second CXCL8 lineage was found in zebrafish and carp only. An early inflammatory function for both lineages was indicated by several lines of evidence. The induction of carp CXCL8s, CXCb, and CXC receptor-1 and -2 was analyzed after in vitro stimulation of leukocyte subpopulations and in two in vivo inflammation models. Recombinant proteins of carp CXCL8 proteins were produced and showed significant chemotactic activity for carp leukocytes.<h4>Conclusions</h4>While both carp CXCL8s appear to be functional homologs of mammalian CXCL8, their different induction requirements and kinetics evoke a gene-specific sub-functionalization.
format	article
author	Lieke M van der Aa Magdalena Chadzinska Edwin Tijhaar Pierre Boudinot B M Lidy Verburg-van Kemenade
author_facet	Lieke M van der Aa Magdalena Chadzinska Edwin Tijhaar Pierre Boudinot B M Lidy Verburg-van Kemenade
author_sort	Lieke M van der Aa
title	CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
title_short	CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
title_full	CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
title_fullStr	CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
title_full_unstemmed	CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
title_sort	cxcl8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/9c13f7be0750438d8a7950b864931ab2
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CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation.

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