FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism

Saccharomyces cerevisiae is a model organism to study proteins involved in neurodegeneration. Here, the authors performed a yeast genome-wide synthetic genetic interaction array (SGA) to screen for toxicity modifiers of Aβ42 and identify riboflavin kinase and its metabolic product flavin mononucleot...

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Autores principales:	Xin Chen, Boyang Ji, Xinxin Hao, Xiaowei Li, Frederik Eisele, Thomas Nyström, Dina Petranovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c14572cb31348da8b839cc360d90b92
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spelling	oai:doaj.org-article:9c14572cb31348da8b839cc360d90b922021-12-02T16:56:32ZFMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism10.1038/s41467-020-14525-42041-1723https://doaj.org/article/9c14572cb31348da8b839cc360d90b922020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14525-4https://doaj.org/toc/2041-1723Saccharomyces cerevisiae is a model organism to study proteins involved in neurodegeneration. Here, the authors performed a yeast genome-wide synthetic genetic interaction array (SGA) to screen for toxicity modifiers of Aβ42 and identify riboflavin kinase and its metabolic product flavin mononucleotide as modulators that alleviate cellular Aβ42 toxicity, which is supported by further experimental analyses.Xin ChenBoyang JiXinxin HaoXiaowei LiFrederik EiseleThomas NyströmDina PetranovicNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Chen Boyang Ji Xinxin Hao Xiaowei Li Frederik Eisele Thomas Nyström Dina Petranovic FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
description	Saccharomyces cerevisiae is a model organism to study proteins involved in neurodegeneration. Here, the authors performed a yeast genome-wide synthetic genetic interaction array (SGA) to screen for toxicity modifiers of Aβ42 and identify riboflavin kinase and its metabolic product flavin mononucleotide as modulators that alleviate cellular Aβ42 toxicity, which is supported by further experimental analyses.
format	article
author	Xin Chen Boyang Ji Xinxin Hao Xiaowei Li Frederik Eisele Thomas Nyström Dina Petranovic
author_facet	Xin Chen Boyang Ji Xinxin Hao Xiaowei Li Frederik Eisele Thomas Nyström Dina Petranovic
author_sort	Xin Chen
title	FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
title_short	FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
title_full	FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
title_fullStr	FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
title_full_unstemmed	FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
title_sort	fmn reduces amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9c14572cb31348da8b839cc360d90b92
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FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism

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