Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on oligodendrocyte progenitor cells, and disruption o...

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Autores principales:	Fucheng Luo, Amanda Phuong Tran, Li Xin, Chandrika Sanapala, Bradley T. Lang, Jerry Silver, Yan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c16454ee374473489e0265861603c15
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spelling	oai:doaj.org-article:9c16454ee374473489e0265861603c152021-12-02T15:34:48ZModulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis10.1038/s41467-018-06505-62041-1723https://doaj.org/article/9c16454ee374473489e0265861603c152018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06505-6https://doaj.org/toc/2041-1723Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on oligodendrocyte progenitor cells, and disruption of this interaction can promote recovery in the animal models of MS.Fucheng LuoAmanda Phuong TranLi XinChandrika SanapalaBradley T. LangJerry SilverYan YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fucheng Luo Amanda Phuong Tran Li Xin Chandrika Sanapala Bradley T. Lang Jerry Silver Yan Yang Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
description	Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on oligodendrocyte progenitor cells, and disruption of this interaction can promote recovery in the animal models of MS.
format	article
author	Fucheng Luo Amanda Phuong Tran Li Xin Chandrika Sanapala Bradley T. Lang Jerry Silver Yan Yang
author_facet	Fucheng Luo Amanda Phuong Tran Li Xin Chandrika Sanapala Bradley T. Lang Jerry Silver Yan Yang
author_sort	Fucheng Luo
title	Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
title_short	Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
title_full	Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
title_fullStr	Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
title_full_unstemmed	Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
title_sort	modulation of proteoglycan receptor ptpσ enhances mmp-2 activity to promote recovery from multiple sclerosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c16454ee374473489e0265861603c15
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Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

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