Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography
Abstract To investigate the correlation between posterior pole choroidal blood flow evaluated with digital subtraction indocyanine green angiography and enface optical coherence tomography angiography (OCTA). Imaging in animal study. The anatomy of 2 cynomogulus monkeys was studied. Each monkey was...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9c1c95a68cb24dafb2dd2eecd3e0f9ee |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:9c1c95a68cb24dafb2dd2eecd3e0f9ee |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:9c1c95a68cb24dafb2dd2eecd3e0f9ee2021-12-02T16:36:36ZCorrelation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography10.1038/s41598-021-95270-62045-2322https://doaj.org/article/9c1c95a68cb24dafb2dd2eecd3e0f9ee2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95270-6https://doaj.org/toc/2045-2322Abstract To investigate the correlation between posterior pole choroidal blood flow evaluated with digital subtraction indocyanine green angiography and enface optical coherence tomography angiography (OCTA). Imaging in animal study. The anatomy of 2 cynomogulus monkeys was studied. Each monkey was given a 0.75 mg/kg injection of indocyanine green in the saphenous vein. The dynamic angiographic filling sequence was recorded at 15 frames per second using the Heidelberg Spectralis. After image registration, sequential frame subtraction was used to image the dye front moving through the choroid. The OCTA was obtained by frame averaging nine separate choriocapillaris slab flow images obtained from the Zeiss Plex Elite 9000. Posterior pole choriocapillaris filling pattern in relation to the choriocapillaris anatomy as imaged by OCTA. In the posterior pole, the choriocapillaris fills in the pattern of discrete units with variable sizes and shapes. The cycle of dye filling begins in the peripapillary area and progresses toward the periphery in a wavelike manner. This filling pattern repeats in a cyclical manner, consistent with the cardiac cycle. OCTA shows a uniform mesh of vessels. While OCTA shows a uniform meshwork appearance of the choriocapillaris, the dynamic dye angiography suggests an irregular configuration of functional units partitioned by pressure gradients as opposed to structural boundaries. Disturbance of local perfusion pressure within choroidal vasculature may result in abnormal flow patterns, which could be evaluated in the clinic using commercially available equipment.Chui Ming Gemmy CheungKelvin Yi Chong TeoSai Bo Bo TunJoanna Marie BusoyVeluchamy A. BarathiRichard F. SpaideNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Veluchamy A. Barathi Richard F. Spaide Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
description |
Abstract To investigate the correlation between posterior pole choroidal blood flow evaluated with digital subtraction indocyanine green angiography and enface optical coherence tomography angiography (OCTA). Imaging in animal study. The anatomy of 2 cynomogulus monkeys was studied. Each monkey was given a 0.75 mg/kg injection of indocyanine green in the saphenous vein. The dynamic angiographic filling sequence was recorded at 15 frames per second using the Heidelberg Spectralis. After image registration, sequential frame subtraction was used to image the dye front moving through the choroid. The OCTA was obtained by frame averaging nine separate choriocapillaris slab flow images obtained from the Zeiss Plex Elite 9000. Posterior pole choriocapillaris filling pattern in relation to the choriocapillaris anatomy as imaged by OCTA. In the posterior pole, the choriocapillaris fills in the pattern of discrete units with variable sizes and shapes. The cycle of dye filling begins in the peripapillary area and progresses toward the periphery in a wavelike manner. This filling pattern repeats in a cyclical manner, consistent with the cardiac cycle. OCTA shows a uniform mesh of vessels. While OCTA shows a uniform meshwork appearance of the choriocapillaris, the dynamic dye angiography suggests an irregular configuration of functional units partitioned by pressure gradients as opposed to structural boundaries. Disturbance of local perfusion pressure within choroidal vasculature may result in abnormal flow patterns, which could be evaluated in the clinic using commercially available equipment. |
format |
article |
author |
Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Veluchamy A. Barathi Richard F. Spaide |
author_facet |
Chui Ming Gemmy Cheung Kelvin Yi Chong Teo Sai Bo Bo Tun Joanna Marie Busoy Veluchamy A. Barathi Richard F. Spaide |
author_sort |
Chui Ming Gemmy Cheung |
title |
Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
title_short |
Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
title_full |
Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
title_fullStr |
Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
title_full_unstemmed |
Correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
title_sort |
correlation of choriocapillaris hemodynamic data from dynamic indocyanine green and optical coherence tomography angiography |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/9c1c95a68cb24dafb2dd2eecd3e0f9ee |
work_keys_str_mv |
AT chuiminggemmycheung correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography AT kelvinyichongteo correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography AT saibobotun correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography AT joannamariebusoy correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography AT veluchamyabarathi correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography AT richardfspaide correlationofchoriocapillarishemodynamicdatafromdynamicindocyaninegreenandopticalcoherencetomographyangiography |
_version_ |
1718383647253331968 |