Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial

Background and Aims. Simethicone (SIM), as an antifoaming agent, has been shown to improve bowel preparation during colonoscopy. However, the optimal timing of SIM addition remained undetermined. We aimed to investigate the optimal timing of SIM addition to polyethylene glycol (PEG) to improve bowel...

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Autores principales:	Zhen-wen Wu, Sheng-gang Zhan, Mei-feng Yang, Yi-teng Meng, Feng Xiong, Cheng Wei, Ying-xue Li, Ding-guo Zhang, Zheng-lei Xu, Ben-hua Wu, Rui-yue Shi, Jun Yao, Li-sheng Wang, De-feng Li
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9c1d5c8ca8be4eb99f1aee5dd9f46008
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spelling	oai:doaj.org-article:9c1d5c8ca8be4eb99f1aee5dd9f460082021-11-08T02:36:37ZOptimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial2291-279710.1155/2021/4032285https://doaj.org/article/9c1d5c8ca8be4eb99f1aee5dd9f460082021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4032285https://doaj.org/toc/2291-2797Background and Aims. Simethicone (SIM), as an antifoaming agent, has been shown to improve bowel preparation during colonoscopy. However, the optimal timing of SIM addition remained undetermined. We aimed to investigate the optimal timing of SIM addition to polyethylene glycol (PEG) to improve bowel preparation. Methods. Eligible patients were randomly assigned to two groups: the SIM evening group (SIM addition to PEG in the evening of the day prior to colonoscopy) and the SIM morning group (SIM addition to PEG in the morning of colonoscopy). The primary outcome was Bubble Scale (BS). The secondary outcomes were Boston Bowel Preparation Scale (BBPS) and adenoma detection rate (ADR). Results. A total of 419 patients were enrolled in this study. The baseline characteristics of the patients were similar in both groups. No significant differences were observed in terms of BS (8.76 ± 0.90 vs. 8.65 ± 1.16, P = 0.81), ADR (34.1% vs. 30.8%, P = 0.47), Boston Bowel Preparation Scale (BBPS) (8.59 ± 0.94 vs. 8.45 ± 1.00, P = 0.15), and withdrawal time (8.22 ± 2.04 vs. 8.01 ± 2.51, P = 0.094) between the two groups. Moreover, safety and compliance were similar in both groups. However, the SIM evening group was associated with shorter cecal intubation time (3.80 ± 1.81 vs. 4.42 ± 2.03, P < 0.001), higher BS (2.95 ± 0.26 vs. 2.88 ± 0.38, P = 0.04) in the right colon, and diminutive ADR (62.5% vs. 38.6%, P = 0.022) in the right colon, when compared to the SIM evening group. Conclusions. The SIM addition to PEG in the evening of the day prior to colonoscopy can shorten cecal intubation time and improve BS scores and diminutive ADR of the right colon compared with the SIM addition to PEG in the morning of colonoscopy in bowel preparation.Zhen-wen WuSheng-gang ZhanMei-feng YangYi-teng MengFeng XiongCheng WeiYing-xue LiDing-guo ZhangZheng-lei XuBen-hua WuRui-yue ShiJun YaoLi-sheng WangDe-feng LiHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENCanadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Zhen-wen Wu Sheng-gang Zhan Mei-feng Yang Yi-teng Meng Feng Xiong Cheng Wei Ying-xue Li Ding-guo Zhang Zheng-lei Xu Ben-hua Wu Rui-yue Shi Jun Yao Li-sheng Wang De-feng Li Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
description	Background and Aims. Simethicone (SIM), as an antifoaming agent, has been shown to improve bowel preparation during colonoscopy. However, the optimal timing of SIM addition remained undetermined. We aimed to investigate the optimal timing of SIM addition to polyethylene glycol (PEG) to improve bowel preparation. Methods. Eligible patients were randomly assigned to two groups: the SIM evening group (SIM addition to PEG in the evening of the day prior to colonoscopy) and the SIM morning group (SIM addition to PEG in the morning of colonoscopy). The primary outcome was Bubble Scale (BS). The secondary outcomes were Boston Bowel Preparation Scale (BBPS) and adenoma detection rate (ADR). Results. A total of 419 patients were enrolled in this study. The baseline characteristics of the patients were similar in both groups. No significant differences were observed in terms of BS (8.76 ± 0.90 vs. 8.65 ± 1.16, P = 0.81), ADR (34.1% vs. 30.8%, P = 0.47), Boston Bowel Preparation Scale (BBPS) (8.59 ± 0.94 vs. 8.45 ± 1.00, P = 0.15), and withdrawal time (8.22 ± 2.04 vs. 8.01 ± 2.51, P = 0.094) between the two groups. Moreover, safety and compliance were similar in both groups. However, the SIM evening group was associated with shorter cecal intubation time (3.80 ± 1.81 vs. 4.42 ± 2.03, P < 0.001), higher BS (2.95 ± 0.26 vs. 2.88 ± 0.38, P = 0.04) in the right colon, and diminutive ADR (62.5% vs. 38.6%, P = 0.022) in the right colon, when compared to the SIM evening group. Conclusions. The SIM addition to PEG in the evening of the day prior to colonoscopy can shorten cecal intubation time and improve BS scores and diminutive ADR of the right colon compared with the SIM addition to PEG in the morning of colonoscopy in bowel preparation.
format	article
author	Zhen-wen Wu Sheng-gang Zhan Mei-feng Yang Yi-teng Meng Feng Xiong Cheng Wei Ying-xue Li Ding-guo Zhang Zheng-lei Xu Ben-hua Wu Rui-yue Shi Jun Yao Li-sheng Wang De-feng Li
author_facet	Zhen-wen Wu Sheng-gang Zhan Mei-feng Yang Yi-teng Meng Feng Xiong Cheng Wei Ying-xue Li Ding-guo Zhang Zheng-lei Xu Ben-hua Wu Rui-yue Shi Jun Yao Li-sheng Wang De-feng Li
author_sort	Zhen-wen Wu
title	Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
title_short	Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
title_full	Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
title_fullStr	Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
title_full_unstemmed	Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial
title_sort	optimal timing of simethicone supplement for bowel preparation: a prospective randomized controlled trial
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9c1d5c8ca8be4eb99f1aee5dd9f46008
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Optimal Timing of Simethicone Supplement for Bowel Preparation: A Prospective Randomized Controlled Trial

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