Vitamin D deficiency and severity of pneumonia in Indonesian children.

<h4>Objective</h4>To determine the prevalence of vitamin D deficiency in Indonesian children hospitalized with pneumonia and evaluate the association between vitamin D status and severity of pneumonia.<h4>Methods</h4>A hospital-based cross-sectional study was conducted from F...

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Autores principales:	Vicka Oktaria, Rina Triasih, Stephen M Graham, Julie E Bines, Yati Soenarto, Michael W Clarke, Mike Lauda, Margaret Danchin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c207dff4bec408f9094598024198d64
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spelling	oai:doaj.org-article:9c207dff4bec408f9094598024198d642021-12-02T20:15:30ZVitamin D deficiency and severity of pneumonia in Indonesian children.1932-620310.1371/journal.pone.0254488https://doaj.org/article/9c207dff4bec408f9094598024198d642021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254488https://doaj.org/toc/1932-6203<h4>Objective</h4>To determine the prevalence of vitamin D deficiency in Indonesian children hospitalized with pneumonia and evaluate the association between vitamin D status and severity of pneumonia.<h4>Methods</h4>A hospital-based cross-sectional study was conducted from February 2016 to July 2017 in two district hospitals in Yogyakarta province, Indonesia. Infants and young children aged 2-59 months hospitalized with pneumonia were recruited. Serum blood samples were collected on admission and analyzed for total serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 concentrations using liquid chromatography-tandem mass spectrometry. Vitamin D deficiency was defined as a level of serum vitamin D <50 nmol/L. The association between vitamin D deficiency and severity of hospitalized pneumonia according to WHO criteria, including the presence of danger signs, hypoxemia (SpO2 in air below 90%), duration of hospitalization, and admission to Intensive Care Unit (ICU), was analyzed using logistic regression.<h4>Results</h4>133 children with WHO-defined pneumonia were enrolled in the study and 127 (96%) had their vitamin D status determined. The mean vitamin D concentration was 67 (± 24 SD) nmol/L and 19% of participants were vitamin D deficient. Age younger than 6 months was associated with prolonged hospitalization (> 5 days) and low birth weight and poor nutritional status on admission were risk factors for hypoxemia. However, vitamin D status was not associated with the presence of danger signs, duration of hospitalization, or hypoxemia.<h4>Conclusions</h4>One in every five children hospitalized with pneumonia was vitamin D deficient. Vitamin D status was not associated with the severity of pneumonia.Vicka OktariaRina TriasihStephen M GrahamJulie E BinesYati SoenartoMichael W ClarkeMike LaudaMargaret DanchinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254488 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vicka Oktaria Rina Triasih Stephen M Graham Julie E Bines Yati Soenarto Michael W Clarke Mike Lauda Margaret Danchin Vitamin D deficiency and severity of pneumonia in Indonesian children.
description	<h4>Objective</h4>To determine the prevalence of vitamin D deficiency in Indonesian children hospitalized with pneumonia and evaluate the association between vitamin D status and severity of pneumonia.<h4>Methods</h4>A hospital-based cross-sectional study was conducted from February 2016 to July 2017 in two district hospitals in Yogyakarta province, Indonesia. Infants and young children aged 2-59 months hospitalized with pneumonia were recruited. Serum blood samples were collected on admission and analyzed for total serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 concentrations using liquid chromatography-tandem mass spectrometry. Vitamin D deficiency was defined as a level of serum vitamin D <50 nmol/L. The association between vitamin D deficiency and severity of hospitalized pneumonia according to WHO criteria, including the presence of danger signs, hypoxemia (SpO2 in air below 90%), duration of hospitalization, and admission to Intensive Care Unit (ICU), was analyzed using logistic regression.<h4>Results</h4>133 children with WHO-defined pneumonia were enrolled in the study and 127 (96%) had their vitamin D status determined. The mean vitamin D concentration was 67 (± 24 SD) nmol/L and 19% of participants were vitamin D deficient. Age younger than 6 months was associated with prolonged hospitalization (> 5 days) and low birth weight and poor nutritional status on admission were risk factors for hypoxemia. However, vitamin D status was not associated with the presence of danger signs, duration of hospitalization, or hypoxemia.<h4>Conclusions</h4>One in every five children hospitalized with pneumonia was vitamin D deficient. Vitamin D status was not associated with the severity of pneumonia.
format	article
author	Vicka Oktaria Rina Triasih Stephen M Graham Julie E Bines Yati Soenarto Michael W Clarke Mike Lauda Margaret Danchin
author_facet	Vicka Oktaria Rina Triasih Stephen M Graham Julie E Bines Yati Soenarto Michael W Clarke Mike Lauda Margaret Danchin
author_sort	Vicka Oktaria
title	Vitamin D deficiency and severity of pneumonia in Indonesian children.
title_short	Vitamin D deficiency and severity of pneumonia in Indonesian children.
title_full	Vitamin D deficiency and severity of pneumonia in Indonesian children.
title_fullStr	Vitamin D deficiency and severity of pneumonia in Indonesian children.
title_full_unstemmed	Vitamin D deficiency and severity of pneumonia in Indonesian children.
title_sort	vitamin d deficiency and severity of pneumonia in indonesian children.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9c207dff4bec408f9094598024198d64
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Vitamin D deficiency and severity of pneumonia in Indonesian children.

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