Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS

Abstract Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. Howev...

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Autores principales:	Daniele Oliveira dos Santos, Larissa Perossi, Jéssica Perossi, Letícia Helena de Souza Simoni, Mayara Holtz, Ricardo Grassi Moroli, José Antônio Baddini-Martinez, Ada Clarice Gastaldi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c2446e776b54b998762dbacaf1a776c
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spelling	oai:doaj.org-article:9c2446e776b54b998762dbacaf1a776c2021-12-02T13:19:21ZComparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS10.1038/s41598-021-84028-92045-2322https://doaj.org/article/9c2446e776b54b998762dbacaf1a776c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84028-9https://doaj.org/toc/2045-2322Abstract Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. However, no data are available in the literature to differentiate between COPD and BE using IOS parameters. We aimed to evaluate the feasibility of IOS in the diagnosis of bronchiectasis non-cystic fibrosis (BE) in comparison to COPD. Whole breath, inspiration, expiration, and inspiratory-expiratory difference (Δ) were evaluated based on the IOS parameters: total resistance (R5), central airway resistance (R20), peripheral airway resistance (R5-R20), reactance (X5), reactance area (AX), and resonance frequency (Fres). Fifty-nine subjects (21 Healthy, 19 BE, and 19 COPD) participated in this study. It was observed a significant difference in the comparison of healthy and pulmonary disease groups (BE and COPD) for total breathing (R5-R20, X5, AX, and Fres), inspiratory phase (R5 and R5-R5), and expiratory phase (R5-R20 and X5). The comparison between BE and COPD groups showed significant difference in the expiratory phase for resistance at 5 and 20 Hz and, ΔR5 and ΔR20. The IOS evidenced an increase of R5, R20 and R5-R20 in patients with BE and COPD when compared to healthy subjects. Expiratory measures of IOS revealed increased airway resistance in COPD compared to BE patients who had similar FEV1 measured by spirometry, however, further studies are needed to confirm these differences.Daniele Oliveira dos SantosLarissa PerossiJéssica PerossiLetícia Helena de Souza SimoniMayara HoltzRicardo Grassi MoroliJosé Antônio Baddini-MartinezAda Clarice GastaldiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniele Oliveira dos Santos Larissa Perossi Jéssica Perossi Letícia Helena de Souza Simoni Mayara Holtz Ricardo Grassi Moroli José Antônio Baddini-Martinez Ada Clarice Gastaldi Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
description	Abstract Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. However, no data are available in the literature to differentiate between COPD and BE using IOS parameters. We aimed to evaluate the feasibility of IOS in the diagnosis of bronchiectasis non-cystic fibrosis (BE) in comparison to COPD. Whole breath, inspiration, expiration, and inspiratory-expiratory difference (Δ) were evaluated based on the IOS parameters: total resistance (R5), central airway resistance (R20), peripheral airway resistance (R5-R20), reactance (X5), reactance area (AX), and resonance frequency (Fres). Fifty-nine subjects (21 Healthy, 19 BE, and 19 COPD) participated in this study. It was observed a significant difference in the comparison of healthy and pulmonary disease groups (BE and COPD) for total breathing (R5-R20, X5, AX, and Fres), inspiratory phase (R5 and R5-R5), and expiratory phase (R5-R20 and X5). The comparison between BE and COPD groups showed significant difference in the expiratory phase for resistance at 5 and 20 Hz and, ΔR5 and ΔR20. The IOS evidenced an increase of R5, R20 and R5-R20 in patients with BE and COPD when compared to healthy subjects. Expiratory measures of IOS revealed increased airway resistance in COPD compared to BE patients who had similar FEV1 measured by spirometry, however, further studies are needed to confirm these differences.
format	article
author	Daniele Oliveira dos Santos Larissa Perossi Jéssica Perossi Letícia Helena de Souza Simoni Mayara Holtz Ricardo Grassi Moroli José Antônio Baddini-Martinez Ada Clarice Gastaldi
author_facet	Daniele Oliveira dos Santos Larissa Perossi Jéssica Perossi Letícia Helena de Souza Simoni Mayara Holtz Ricardo Grassi Moroli José Antônio Baddini-Martinez Ada Clarice Gastaldi
author_sort	Daniele Oliveira dos Santos
title	Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
title_short	Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
title_full	Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
title_fullStr	Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
title_full_unstemmed	Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
title_sort	comparative evaluation of expiratory airflow limitation between patients with copd and be using ios
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c2446e776b54b998762dbacaf1a776c
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Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS

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