Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chik...

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Autores principales:	Daniel P. Demarque, Laila S. Espindola
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Aedes aegypti insecticides natural products drug discovery arboviral vectors dengue Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9c258a25964949b58a163ea3317d9936
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spelling	oai:doaj.org-article:9c258a25964949b58a163ea3317d99362021-11-15T06:19:35ZChallenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors2296-264610.3389/fchem.2021.779049https://doaj.org/article/9c258a25964949b58a163ea3317d99362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.779049/fullhttps://doaj.org/toc/2296-2646Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes. Moreover, we analyze the bottlenecks that should be addressed, together with potential strategies, to rationalize and improve the efficiency of the drug discovery process.Daniel P. DemarqueDaniel P. DemarqueLaila S. EspindolaFrontiers Media S.A.articleAedes aegyptiinsecticidesnatural productsdrug discoveryarboviral vectorsdengueChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aedes aegypti insecticides natural products drug discovery arboviral vectors dengue Chemistry QD1-999
spellingShingle	Aedes aegypti insecticides natural products drug discovery arboviral vectors dengue Chemistry QD1-999 Daniel P. Demarque Daniel P. Demarque Laila S. Espindola Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
description	Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes. Moreover, we analyze the bottlenecks that should be addressed, together with potential strategies, to rationalize and improve the efficiency of the drug discovery process.
format	article
author	Daniel P. Demarque Daniel P. Demarque Laila S. Espindola
author_facet	Daniel P. Demarque Daniel P. Demarque Laila S. Espindola
author_sort	Daniel P. Demarque
title	Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
title_short	Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
title_full	Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
title_fullStr	Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
title_full_unstemmed	Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors
title_sort	challenges, advances and opportunities in exploring natural products to control arboviral disease vectors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9c258a25964949b58a163ea3317d9936
work_keys_str_mv	AT danielpdemarque challengesadvancesandopportunitiesinexploringnaturalproductstocontrolarboviraldiseasevectors AT danielpdemarque challengesadvancesandopportunitiesinexploringnaturalproductstocontrolarboviraldiseasevectors AT lailasespindola challengesadvancesandopportunitiesinexploringnaturalproductstocontrolarboviraldiseasevectors
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Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

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