SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.

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Autores principales:	Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c2915beac40413f8c56308a467df541
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spelling	oai:doaj.org-article:9c2915beac40413f8c56308a467df5412021-12-02T18:02:41ZSMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity10.1038/s41467-021-24046-32041-1723https://doaj.org/article/9c2915beac40413f8c56308a467df5412021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24046-3https://doaj.org/toc/2041-1723Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.Volker BoehmSabrina KueckelmannJennifer V. GerbrachtSebastian KallabisThiago Britto-BorgesJanine AltmüllerMarcus KrügerChristoph DieterichNiels H. GehringNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
description	Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.
format	article
author	Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring
author_facet	Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring
author_sort	Volker Boehm
title	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_short	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_full	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_fullStr	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_full_unstemmed	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_sort	smg5-smg7 authorize nonsense-mediated mrna decay by enabling smg6 endonucleolytic activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c2915beac40413f8c56308a467df541
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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

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