Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia
Auliya A Suwantika,1– 3 Angga P Kautsar,4,5 Neily Zakiyah,1,2 Rizky Abdulah,1,2 Cornelis Boersma,6 Maarten J Postma2,5– 7 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 2Center of Excellence in Higher Education...
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Dove Medical Press
2020
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gross expenditure on research and development (gerd) health and medical sciences innovative product cost-effective incremental cost-effectiveness ratio (icer) Therapeutics. Pharmacology RM1-950 |
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gross expenditure on research and development (gerd) health and medical sciences innovative product cost-effective incremental cost-effectiveness ratio (icer) Therapeutics. Pharmacology RM1-950 Suwantika AA Kautsar AP Zakiyah N Abdulah R Boersma C Postma MJ Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
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Auliya A Suwantika,1– 3 Angga P Kautsar,4,5 Neily Zakiyah,1,2 Rizky Abdulah,1,2 Cornelis Boersma,6 Maarten J Postma2,5– 7 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 2Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia; 3Center for Health Technology Assessment, Universitas Padjadjaran, Bandung, Indonesia; 4Department of Pharmaceutical and Pharmacy Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 5Unit of Global Health, Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 6Department of Economics, Econometrics & Finance, Faculty of Economics & Business, University of Groningen, Groningen, The Netherlands; 7Unit of Pharmaco-Therapy, -Epidemiology & -Economics, University of Groningen, Department of Pharmacy, Groningen, The NetherlandsCorrespondence: Auliya A SuwantikaFaculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaEmail auliya@unpad.ac.idBackground: The annual gross domestic expenditure on research and development (GERD) per capita of Indonesia ($24) remains relatively lower than the annual GERD per capita of neighboring countries, such as Vietnam ($36), Singapore ($1804), Malaysia ($361), and Thailand ($111).Objective: The aim of this study was to conduct a cost-effectiveness analysis of spending on healthcare R&D to address the needs of developing innovative therapeutic products in Indonesia.Methods: A decision tree model was developed by taking into account four stages of R&D: stage 1 from raw concept to feasibility, stage 2 from feasibility to development, stage 3 from development to early commercialization, and stage 4 from early to full commercialization. Considering a 3-year time horizon, a stage-dependent success rate was applied and analyses were conducted from a business perspective. Two scenarios were compared by assuming the government of Indonesia would increase GERD in health and medical sciences up to 2- and 3-times higher than the baseline (current situation) for the first and second scenario, respectively. Cost per number of innovative products in health and medical sciences was considered as the incremental cost-effectiveness ratio (ICER). Univariate sensitivity analysis was conducted to investigate the effects of different input parameters on the ICER.Results: There was a statistically significant association (P-value< 0.05) between countries’ GERD in medical and health sciences with the number of innovative products. We estimated the ICER would be $8.50 million and $2.04 million per innovative product for the first and second scenario, respectively. The sensitivity analysis showed that the success rates in all stages and total GERD were the most influential parameters impacting the ICER.Conclusion: The result showed that there was an association between GERD in medical and health sciences with the number of innovative products. In addition, the second scenario would be more cost-effective than the first scenario.Keywords: GERD, health and medical sciences, innovative product, cost-effective, ICER |
| format |
article |
| author |
Suwantika AA Kautsar AP Zakiyah N Abdulah R Boersma C Postma MJ |
| author_facet |
Suwantika AA Kautsar AP Zakiyah N Abdulah R Boersma C Postma MJ |
| author_sort |
Suwantika AA |
| title |
Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
| title_short |
Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
| title_full |
Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
| title_fullStr |
Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
| title_full_unstemmed |
Cost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia |
| title_sort |
cost-effectiveness analysis of spending on research and development to address the needs for innovative therapeutic products in indonesia |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/9c29a55fe4974eb99423d803e5b3f14c |
| work_keys_str_mv |
AT suwantikaaa costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia AT kautsarap costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia AT zakiyahn costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia AT abdulahr costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia AT boersmac costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia AT postmamj costeffectivenessanalysisofspendingonresearchanddevelopmenttoaddresstheneedsforinnovativetherapeuticproductsinindonesia |
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oai:doaj.org-article:9c29a55fe4974eb99423d803e5b3f14c2021-12-02T11:10:51ZCost-Effectiveness Analysis of Spending on Research and Development to Address the Needs for Innovative Therapeutic Products in Indonesia1178-203Xhttps://doaj.org/article/9c29a55fe4974eb99423d803e5b3f14c2020-10-01T00:00:00Zhttps://www.dovepress.com/cost-effectiveness-analysis-of-spending-on-research-and-development-to-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XAuliya A Suwantika,1– 3 Angga P Kautsar,4,5 Neily Zakiyah,1,2 Rizky Abdulah,1,2 Cornelis Boersma,6 Maarten J Postma2,5– 7 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 2Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia; 3Center for Health Technology Assessment, Universitas Padjadjaran, Bandung, Indonesia; 4Department of Pharmaceutical and Pharmacy Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 5Unit of Global Health, Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 6Department of Economics, Econometrics & Finance, Faculty of Economics & Business, University of Groningen, Groningen, The Netherlands; 7Unit of Pharmaco-Therapy, -Epidemiology & -Economics, University of Groningen, Department of Pharmacy, Groningen, The NetherlandsCorrespondence: Auliya A SuwantikaFaculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, IndonesiaEmail auliya@unpad.ac.idBackground: The annual gross domestic expenditure on research and development (GERD) per capita of Indonesia ($24) remains relatively lower than the annual GERD per capita of neighboring countries, such as Vietnam ($36), Singapore ($1804), Malaysia ($361), and Thailand ($111).Objective: The aim of this study was to conduct a cost-effectiveness analysis of spending on healthcare R&D to address the needs of developing innovative therapeutic products in Indonesia.Methods: A decision tree model was developed by taking into account four stages of R&D: stage 1 from raw concept to feasibility, stage 2 from feasibility to development, stage 3 from development to early commercialization, and stage 4 from early to full commercialization. Considering a 3-year time horizon, a stage-dependent success rate was applied and analyses were conducted from a business perspective. Two scenarios were compared by assuming the government of Indonesia would increase GERD in health and medical sciences up to 2- and 3-times higher than the baseline (current situation) for the first and second scenario, respectively. Cost per number of innovative products in health and medical sciences was considered as the incremental cost-effectiveness ratio (ICER). Univariate sensitivity analysis was conducted to investigate the effects of different input parameters on the ICER.Results: There was a statistically significant association (P-value< 0.05) between countries’ GERD in medical and health sciences with the number of innovative products. We estimated the ICER would be $8.50 million and $2.04 million per innovative product for the first and second scenario, respectively. The sensitivity analysis showed that the success rates in all stages and total GERD were the most influential parameters impacting the ICER.Conclusion: The result showed that there was an association between GERD in medical and health sciences with the number of innovative products. In addition, the second scenario would be more cost-effective than the first scenario.Keywords: GERD, health and medical sciences, innovative product, cost-effective, ICERSuwantika AAKautsar APZakiyah NAbdulah RBoersma CPostma MJDove Medical Pressarticlegross expenditure on research and development (gerd)health and medical sciencesinnovative productcost-effectiveincremental cost-effectiveness ratio (icer)Therapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 969-977 (2020) |