Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts

Background Non-invasive biomarkers for the assessment of disease severity in idiopathic pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins produced by neutrophils, which likely contribute to IPF pathogenesis. Calprotectin is a well-established biomarker in infla...

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Autores principales:	Maria Molina-Molina, Carlos Machahua, Sabina A. Guler, Michael P. Horn, Lurdes Planas-Cerezales, Ana Montes-Worboys, Thomas K. Geiser, Manuela Funke-Chambour
Formato:	article
Lenguaje:	EN
Publicado:	BMJ Publishing Group 2021
Materias:	Medicine R Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/9c29f3d8a4784a128929e9c462286e17
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spelling	oai:doaj.org-article:9c29f3d8a4784a128929e9c462286e172021-11-17T06:30:05ZSerum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts10.1136/bmjresp-2020-0008272052-4439https://doaj.org/article/9c29f3d8a4784a128929e9c462286e172021-11-01T00:00:00Zhttps://bmjopenrespres.bmj.com/content/8/1/e000827.fullhttps://doaj.org/toc/2052-4439Background Non-invasive biomarkers for the assessment of disease severity in idiopathic pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins produced by neutrophils, which likely contribute to IPF pathogenesis. Calprotectin is a well-established biomarker in inflammatory bowel diseases. In this cross-sectional study, we aimed to establish the potential role of calprotectin as a biomarker in IPF. Specifically, we hypothesised that patients with IPF have higher serum calprotectin levels compared with healthy controls, and that calprotectin levels are associated with disease severity.Methods Blood samples were obtained from healthy volunteers (n=26) and from two independent IPF cohorts (derivation cohort n=26, validation cohort n=66). Serum calprotectin levels were measured with a commercial kit adapted for that purpose and compared between healthy controls and patients with IPF. Clinical parameters, including forced vital capacity, diffusing capacity for carbon monoxide (DLCO) and the Composite Physiologic Index (CPI), were correlated with calprotectin serum levels.Results The IPF derivation cohort showed increased serum calprotectin levels compared with healthy controls (2.47±1.67 vs 0.97±0.53 µg/mL, p<0.001). In addition, serum calprotectin levels correlated with DLCO% predicted (r=−0.53, p=0.007) and with CPI (r=0.66, p=0.007). These findings were confirmed in an independent IPF validation cohort.Conclusion Serum calprotectin levels are significantly increased in patients with IPF compared with healthy controls and correlate with DLCO and CPI. Calprotectin might be a potential new biomarker for disease severity in IPF.Maria Molina-MolinaCarlos MachahuaSabina A. GulerMichael P. HornLurdes Planas-CerezalesAna Montes-WorboysThomas K. GeiserManuela Funke-ChambourBMJ Publishing GrouparticleMedicineRDiseases of the respiratory systemRC705-779ENBMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Diseases of the respiratory system RC705-779
spellingShingle	Medicine R Diseases of the respiratory system RC705-779 Maria Molina-Molina Carlos Machahua Sabina A. Guler Michael P. Horn Lurdes Planas-Cerezales Ana Montes-Worboys Thomas K. Geiser Manuela Funke-Chambour Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
description	Background Non-invasive biomarkers for the assessment of disease severity in idiopathic pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins produced by neutrophils, which likely contribute to IPF pathogenesis. Calprotectin is a well-established biomarker in inflammatory bowel diseases. In this cross-sectional study, we aimed to establish the potential role of calprotectin as a biomarker in IPF. Specifically, we hypothesised that patients with IPF have higher serum calprotectin levels compared with healthy controls, and that calprotectin levels are associated with disease severity.Methods Blood samples were obtained from healthy volunteers (n=26) and from two independent IPF cohorts (derivation cohort n=26, validation cohort n=66). Serum calprotectin levels were measured with a commercial kit adapted for that purpose and compared between healthy controls and patients with IPF. Clinical parameters, including forced vital capacity, diffusing capacity for carbon monoxide (DLCO) and the Composite Physiologic Index (CPI), were correlated with calprotectin serum levels.Results The IPF derivation cohort showed increased serum calprotectin levels compared with healthy controls (2.47±1.67 vs 0.97±0.53 µg/mL, p<0.001). In addition, serum calprotectin levels correlated with DLCO% predicted (r=−0.53, p=0.007) and with CPI (r=0.66, p=0.007). These findings were confirmed in an independent IPF validation cohort.Conclusion Serum calprotectin levels are significantly increased in patients with IPF compared with healthy controls and correlate with DLCO and CPI. Calprotectin might be a potential new biomarker for disease severity in IPF.
format	article
author	Maria Molina-Molina Carlos Machahua Sabina A. Guler Michael P. Horn Lurdes Planas-Cerezales Ana Montes-Worboys Thomas K. Geiser Manuela Funke-Chambour
author_facet	Maria Molina-Molina Carlos Machahua Sabina A. Guler Michael P. Horn Lurdes Planas-Cerezales Ana Montes-Worboys Thomas K. Geiser Manuela Funke-Chambour
author_sort	Maria Molina-Molina
title	Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
title_short	Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
title_full	Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
title_fullStr	Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
title_full_unstemmed	Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
title_sort	serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts
publisher	BMJ Publishing Group
publishDate	2021
url	https://doaj.org/article/9c29f3d8a4784a128929e9c462286e17
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Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts

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