Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion

Abstract Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiangtao Sheng, Jinhua Yang, Shirong Cai, Dongzhou Zhuang, Tian Li, Xiaoxuan Chen, Gefei Wang, Jianping Dai, Faxiu Ding, Lu Tian, Fengqing Zheng, Fei Tian, Mindong Huang, Kangsheng Li, Weiqiang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c2a9a02921b4f6696a03155de1f154b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c2a9a02921b4f6696a03155de1f154b
record_format	dspace
spelling	oai:doaj.org-article:9c2a9a02921b4f6696a03155de1f154b2021-12-02T10:49:29ZDevelopment and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion10.1038/s41598-021-81685-82045-2322https://doaj.org/article/9c2a9a02921b4f6696a03155de1f154b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81685-8https://doaj.org/toc/2045-2322Abstract Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predict acute tICH expansion. In this multicenter, prospective cohort study, multihematoma fuzzy signs on baseline CT were found in 212 (43.89%) of total 482 patients. Patients with the multihematoma fuzzy sign had a higher frequency of tICH expansion than those without (90.79% (138) vs. 46.71% (71)). The presence of multihematoma fuzzy sign was associated with increased risk for acute tICH expansion in entire cohort (odds ratio [OR]: 16.15; 95% confidence interval (CI) 8.85–29.47; P < 0.001) and in the cohort after propensity-score matching (OR: 9.37; 95% CI 4.52–19.43; P < 0.001). Receiver operating characteristic analysis indicated a better discriminative ability of the presence of multihematoma fuzzy sign for acute tICH expansion (AUC = 0.79; 95% CI 0.76–0.83), as was also observed in an external validation cohort (AUC = 0.76; 95% CI 0.67–0.84). The novel NCCT marker of multihematoma fuzzy sign could be easily identified on baseline CT and is an easy-to-use predictive tool for tICH expansion in the early stage of cerebral contusion.Jiangtao ShengJinhua YangShirong CaiDongzhou ZhuangTian LiXiaoxuan ChenGefei WangJianping DaiFaxiu DingLu TianFengqing ZhengFei TianMindong HuangKangsheng LiWeiqiang ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiangtao Sheng Jinhua Yang Shirong Cai Dongzhou Zhuang Tian Li Xiaoxuan Chen Gefei Wang Jianping Dai Faxiu Ding Lu Tian Fengqing Zheng Fei Tian Mindong Huang Kangsheng Li Weiqiang Chen Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
description	Abstract Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predict acute tICH expansion. In this multicenter, prospective cohort study, multihematoma fuzzy signs on baseline CT were found in 212 (43.89%) of total 482 patients. Patients with the multihematoma fuzzy sign had a higher frequency of tICH expansion than those without (90.79% (138) vs. 46.71% (71)). The presence of multihematoma fuzzy sign was associated with increased risk for acute tICH expansion in entire cohort (odds ratio [OR]: 16.15; 95% confidence interval (CI) 8.85–29.47; P < 0.001) and in the cohort after propensity-score matching (OR: 9.37; 95% CI 4.52–19.43; P < 0.001). Receiver operating characteristic analysis indicated a better discriminative ability of the presence of multihematoma fuzzy sign for acute tICH expansion (AUC = 0.79; 95% CI 0.76–0.83), as was also observed in an external validation cohort (AUC = 0.76; 95% CI 0.67–0.84). The novel NCCT marker of multihematoma fuzzy sign could be easily identified on baseline CT and is an easy-to-use predictive tool for tICH expansion in the early stage of cerebral contusion.
format	article
author	Jiangtao Sheng Jinhua Yang Shirong Cai Dongzhou Zhuang Tian Li Xiaoxuan Chen Gefei Wang Jianping Dai Faxiu Ding Lu Tian Fengqing Zheng Fei Tian Mindong Huang Kangsheng Li Weiqiang Chen
author_facet	Jiangtao Sheng Jinhua Yang Shirong Cai Dongzhou Zhuang Tian Li Xiaoxuan Chen Gefei Wang Jianping Dai Faxiu Ding Lu Tian Fengqing Zheng Fei Tian Mindong Huang Kangsheng Li Weiqiang Chen
author_sort	Jiangtao Sheng
title	Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
title_short	Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
title_full	Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
title_fullStr	Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
title_full_unstemmed	Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
title_sort	development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c2a9a02921b4f6696a03155de1f154b
work_keys_str_mv	AT jiangtaosheng developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT jinhuayang developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT shirongcai developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT dongzhouzhuang developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT tianli developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT xiaoxuanchen developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT gefeiwang developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT jianpingdai developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT faxiuding developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT lutian developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT fengqingzheng developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT feitian developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT mindonghuang developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT kangshengli developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion AT weiqiangchen developmentandexternalvalidationofanovelmultihematomafuzzysignoncomputedtomographyforpredictingtraumaticintraparenchymalhematomaexpansion
_version_	1718396607610748928

Development and external validation of a novel multihematoma fuzzy sign on computed tomography for predicting traumatic intraparenchymal hematoma expansion

Ejemplares similares