Evidence of Borrelia theileri in Wild and Domestic Animals in the Kafue Ecosystem of Zambia

Members of the genus Borrelia are arthropod-borne spirochetes that are human and animal pathogens. Vertebrate hosts, including wild animals, are pivotal to the circulation and maintenance of Borrelia spirochetes. However, information on Borrelia</i&g...

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Autores principales:	Yongjin Qiu, David Squarre, Yukiko Nakamura, Alice C. C. Lau, Lavel Chinyama Moonga, Naoko Kawai, Aiko Ohnuma, Kyoko Hayashida, Ryo Nakao, Junya Yamagishi, Hirofumi Sawa, Boniface Namangala, Hiroki Kawabata
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Borrelia theileri</i> cattle impala Kafue national park Zambia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9c2a9d5177cd41a98de72c1a683167a0
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spelling	oai:doaj.org-article:9c2a9d5177cd41a98de72c1a683167a02021-11-25T18:25:45ZEvidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia10.3390/microorganisms91124052076-2607https://doaj.org/article/9c2a9d5177cd41a98de72c1a683167a02021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2405https://doaj.org/toc/2076-2607Members of the genus <i>Borrelia</i> are arthropod-borne spirochetes that are human and animal pathogens. Vertebrate hosts, including wild animals, are pivotal to the circulation and maintenance of <i>Borrelia</i> spirochetes. However, information on <i>Borrelia</i> spirochetes in vertebrate hosts in Zambia is limited. Thus, we aimed to investigate the presence of <i>Borrelia</i> spirochetes in wild animals and cattle in Zambia. A total of 140 wild animals of four species and 488 cattle DNA samples from /near the Kafue National Park were collected for real-time PCR screening, followed by characterization using three different genes with positive samples. Five impalas and 20 cattle tested positive using real-time PCR, and sequence analysis revealed that the detected <i>Borrelia</i> were identified to be <i>Borrelia theileri,</i> a causative agent of bovine borreliosis. This is the first evidence of <i>Borrelia theileri</i> in African wildlife and cattle in Zambia. Our results suggest that clinical differentiation between bovine borreliosis and other bovine diseases endemic in Zambia is required for better treatment and control measures. As this study only included wild and domestic animals in the Kafue ecosystem, further investigations in other areas and with more wildlife and livestock species are needed to clarify a comprehensive epidemiological status of <i>Borrelia theileri</i> in Zambia.Yongjin QiuDavid SquarreYukiko NakamuraAlice C. C. LauLavel Chinyama MoongaNaoko KawaiAiko OhnumaKyoko HayashidaRyo NakaoJunya YamagishiHirofumi SawaBoniface NamangalaHiroki KawabataMDPI AGarticle<i>Borrelia theileri</i>cattleimpalaKafue national parkZambiaBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2405, p 2405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Borrelia theileri</i> cattle impala Kafue national park Zambia Biology (General) QH301-705.5
spellingShingle	<i>Borrelia theileri</i> cattle impala Kafue national park Zambia Biology (General) QH301-705.5 Yongjin Qiu David Squarre Yukiko Nakamura Alice C. C. Lau Lavel Chinyama Moonga Naoko Kawai Aiko Ohnuma Kyoko Hayashida Ryo Nakao Junya Yamagishi Hirofumi Sawa Boniface Namangala Hiroki Kawabata Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
description	Members of the genus <i>Borrelia</i> are arthropod-borne spirochetes that are human and animal pathogens. Vertebrate hosts, including wild animals, are pivotal to the circulation and maintenance of <i>Borrelia</i> spirochetes. However, information on <i>Borrelia</i> spirochetes in vertebrate hosts in Zambia is limited. Thus, we aimed to investigate the presence of <i>Borrelia</i> spirochetes in wild animals and cattle in Zambia. A total of 140 wild animals of four species and 488 cattle DNA samples from /near the Kafue National Park were collected for real-time PCR screening, followed by characterization using three different genes with positive samples. Five impalas and 20 cattle tested positive using real-time PCR, and sequence analysis revealed that the detected <i>Borrelia</i> were identified to be <i>Borrelia theileri,</i> a causative agent of bovine borreliosis. This is the first evidence of <i>Borrelia theileri</i> in African wildlife and cattle in Zambia. Our results suggest that clinical differentiation between bovine borreliosis and other bovine diseases endemic in Zambia is required for better treatment and control measures. As this study only included wild and domestic animals in the Kafue ecosystem, further investigations in other areas and with more wildlife and livestock species are needed to clarify a comprehensive epidemiological status of <i>Borrelia theileri</i> in Zambia.
format	article
author	Yongjin Qiu David Squarre Yukiko Nakamura Alice C. C. Lau Lavel Chinyama Moonga Naoko Kawai Aiko Ohnuma Kyoko Hayashida Ryo Nakao Junya Yamagishi Hirofumi Sawa Boniface Namangala Hiroki Kawabata
author_facet	Yongjin Qiu David Squarre Yukiko Nakamura Alice C. C. Lau Lavel Chinyama Moonga Naoko Kawai Aiko Ohnuma Kyoko Hayashida Ryo Nakao Junya Yamagishi Hirofumi Sawa Boniface Namangala Hiroki Kawabata
author_sort	Yongjin Qiu
title	Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
title_short	Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
title_full	Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
title_fullStr	Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
title_full_unstemmed	Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia
title_sort	evidence of <i>borrelia theileri</i> in wild and domestic animals in the kafue ecosystem of zambia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9c2a9d5177cd41a98de72c1a683167a0
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Evidence of <i>Borrelia theileri</i> in Wild and Domestic Animals in the Kafue Ecosystem of Zambia

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