Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.

Statins are some of the most commonly prescribed drugs and are used to reduce blood cholesterol. Recent evidence suggests that, in some patients, they may adversely influence cognitive function including causing memory impairments. These clinical observations have led to statin prescriptions now inc...

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Autores principales:	Sarah A Stuart, James D Robertson, Neil V Marrion, Emma S J Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c2b0fb4850247efbe1aa3088bf7102e
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spelling	oai:doaj.org-article:9c2b0fb4850247efbe1aa3088bf7102e2021-11-18T08:55:55ZChronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.1932-620310.1371/journal.pone.0075467https://doaj.org/article/9c2b0fb4850247efbe1aa3088bf7102e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040413/?tool=EBIhttps://doaj.org/toc/1932-6203Statins are some of the most commonly prescribed drugs and are used to reduce blood cholesterol. Recent evidence suggests that, in some patients, they may adversely influence cognitive function including causing memory impairments. These clinical observations have led to statin prescriptions now including a warning about possible cognitive impairments. In order to better understand the relationship between statin treatment and cognitive function, studies in animals are needed. The present study investigated the effects of chronic treatment with two statins, pravastatin and atorvastatin, in two rodent models of learning and memory. Adult rats were treated once daily with pravastatin (10 mg/kg, orally) or atorvostatin (10 mg/kg, orally) for 18 days. Before, during and after treatment, animals were tested in a simple discrimination and reversal learning task. On the last day of treatment and following one week withdrawal, animals were also tested in a task of novel object discrimination. Pravastatin tended to impair learning over the last few days of treatment and this effect was fully reversed once treatment ceased. In the novel object discrimination task, pravastatin significantly impaired object recognition memory. No effects were observed for atorvostatin in either task. These data suggest that chronic treatment with pravastatin impairs working and recognition memory in rodents. The reversibility of the effects on cessation of treatment is similar to what has been observed in patients, but the lack of effect of atorvostatin suggests that lipophilicity may not be a major factor influencing statin-induced cognitive impairments.Sarah A StuartJames D RobertsonNeil V MarrionEmma S J RobinsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75467 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah A Stuart James D Robertson Neil V Marrion Emma S J Robinson Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
description	Statins are some of the most commonly prescribed drugs and are used to reduce blood cholesterol. Recent evidence suggests that, in some patients, they may adversely influence cognitive function including causing memory impairments. These clinical observations have led to statin prescriptions now including a warning about possible cognitive impairments. In order to better understand the relationship between statin treatment and cognitive function, studies in animals are needed. The present study investigated the effects of chronic treatment with two statins, pravastatin and atorvastatin, in two rodent models of learning and memory. Adult rats were treated once daily with pravastatin (10 mg/kg, orally) or atorvostatin (10 mg/kg, orally) for 18 days. Before, during and after treatment, animals were tested in a simple discrimination and reversal learning task. On the last day of treatment and following one week withdrawal, animals were also tested in a task of novel object discrimination. Pravastatin tended to impair learning over the last few days of treatment and this effect was fully reversed once treatment ceased. In the novel object discrimination task, pravastatin significantly impaired object recognition memory. No effects were observed for atorvostatin in either task. These data suggest that chronic treatment with pravastatin impairs working and recognition memory in rodents. The reversibility of the effects on cessation of treatment is similar to what has been observed in patients, but the lack of effect of atorvostatin suggests that lipophilicity may not be a major factor influencing statin-induced cognitive impairments.
format	article
author	Sarah A Stuart James D Robertson Neil V Marrion Emma S J Robinson
author_facet	Sarah A Stuart James D Robertson Neil V Marrion Emma S J Robinson
author_sort	Sarah A Stuart
title	Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
title_short	Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
title_full	Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
title_fullStr	Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
title_full_unstemmed	Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
title_sort	chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9c2b0fb4850247efbe1aa3088bf7102e
work_keys_str_mv	AT sarahastuart chronicpravastatinbutnotatorvastatintreatmentimpairscognitivefunctionintworodentmodelsoflearningandmemory AT jamesdrobertson chronicpravastatinbutnotatorvastatintreatmentimpairscognitivefunctionintworodentmodelsoflearningandmemory AT neilvmarrion chronicpravastatinbutnotatorvastatintreatmentimpairscognitivefunctionintworodentmodelsoflearningandmemory AT emmasjrobinson chronicpravastatinbutnotatorvastatintreatmentimpairscognitivefunctionintworodentmodelsoflearningandmemory
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Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory.

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