A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus

Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to t...

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Autores principales:	Jian-Wei Shao, Luan-Ying Guo, Yao-Xian Yuan, Jun Ma, Ji-Ming Chen, Quan Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bovine hepacivirus novel subtype genetic diversity evolution tick China Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9c2b4105f5d3461a95aa0a7a0f36da43
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spelling	oai:doaj.org-article:9c2b4105f5d3461a95aa0a7a0f36da432021-11-25T19:13:20ZA Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus10.3390/v131122061999-4915https://doaj.org/article/9c2b4105f5d3461a95aa0a7a0f36da432021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2206https://doaj.org/toc/1999-4915Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or persistent infections in cattle. BovHepVs are distributed worldwide and classified into two genotypes with seven subtypes in genotype 1. In this study, three BovHepV strains were identified in the samples of ticks sucking blood on cattle in the Guangdong province of China, through unbiased high-throughput sequencing. Genetic analysis revealed the polyprotein-coding gene of these viral sequences herein shared 67.7–84.8% nt identity and 76.1–95.6% aa identity with other BovHepVs identified worldwide. As per the demarcation criteria adopted for the genotyping and subtyping of HCV, these three BovHepV strains belonged to a novel subtype within the genotype 1. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of BovHepV, and genetic recombination was not common among BovHepVs. These results expand the knowledge about the genetic diversity and evolution of BovHepV distributed globally, and also indicate genetically divergent BovHepV strains were co-circulating in cattle populations in China.Jian-Wei ShaoLuan-Ying GuoYao-Xian YuanJun MaJi-Ming ChenQuan LiuMDPI AGarticlebovine hepacivirusnovel subtypegenetic diversityevolutiontickChinaMicrobiologyQR1-502ENViruses, Vol 13, Iss 2206, p 2206 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bovine hepacivirus novel subtype genetic diversity evolution tick China Microbiology QR1-502
spellingShingle	bovine hepacivirus novel subtype genetic diversity evolution tick China Microbiology QR1-502 Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
description	Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or persistent infections in cattle. BovHepVs are distributed worldwide and classified into two genotypes with seven subtypes in genotype 1. In this study, three BovHepV strains were identified in the samples of ticks sucking blood on cattle in the Guangdong province of China, through unbiased high-throughput sequencing. Genetic analysis revealed the polyprotein-coding gene of these viral sequences herein shared 67.7–84.8% nt identity and 76.1–95.6% aa identity with other BovHepVs identified worldwide. As per the demarcation criteria adopted for the genotyping and subtyping of HCV, these three BovHepV strains belonged to a novel subtype within the genotype 1. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of BovHepV, and genetic recombination was not common among BovHepVs. These results expand the knowledge about the genetic diversity and evolution of BovHepV distributed globally, and also indicate genetically divergent BovHepV strains were co-circulating in cattle populations in China.
format	article
author	Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu
author_facet	Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu
author_sort	Jian-Wei Shao
title	A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
title_short	A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
title_full	A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
title_fullStr	A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
title_full_unstemmed	A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
title_sort	novel subtype of bovine hepacivirus identified in ticks reveals the genetic diversity and evolution of bovine hepacivirus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9c2b4105f5d3461a95aa0a7a0f36da43
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A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus

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