The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges
Nearly 50 different mouse retinal ganglion cell (RGC) types sample the visual scene for distinct features. RGC feature selectivity arises from their synapses with a specific subset of amacrine (AC) and bipolar cell (BC) types, but how RGC dendrites arborize and collect input from these specific subs...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
eLife Sciences Publications Ltd
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9c2d1d854d654d6193b4f384be51f90d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9c2d1d854d654d6193b4f384be51f90d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9c2d1d854d654d6193b4f384be51f90d2021-12-01T12:15:05ZThe cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges10.7554/eLife.708702050-084Xe70870https://doaj.org/article/9c2d1d854d654d6193b4f384be51f90d2021-09-01T00:00:00Zhttps://elifesciences.org/articles/70870https://doaj.org/toc/2050-084XNearly 50 different mouse retinal ganglion cell (RGC) types sample the visual scene for distinct features. RGC feature selectivity arises from their synapses with a specific subset of amacrine (AC) and bipolar cell (BC) types, but how RGC dendrites arborize and collect input from these specific subsets remains poorly understood. Here we examine the hypothesis that RGCs employ molecular recognition systems to meet this challenge. By combining calcium imaging and type-specific histological stains, we define a family of circuits that express the recognition molecule Sidekick-1 (Sdk1), which include a novel RGC type (S1-RGC) that responds to local edges. Genetic and physiological studies revealed that Sdk1 loss selectively disrupts S1-RGC visual responses, which result from a loss of excitatory and inhibitory inputs and selective dendritic deficits on this neuron. We conclude that Sdk1 shapes dendrite growth and wiring to help S1-RGCs become feature selective.Pierre-Luc RochonCatherine TheriaultAline Giselle Rangel OlguinArjun KrishnaswamyeLife Sciences Publications Ltdarticleretinal circuitryneurodevelopmentcalcium imagingtwo-photonimmunoglobulin superfamilyretinal ganlgion cellsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
retinal circuitry neurodevelopment calcium imaging two-photon immunoglobulin superfamily retinal ganlgion cells Medicine R Science Q Biology (General) QH301-705.5 |
| spellingShingle |
retinal circuitry neurodevelopment calcium imaging two-photon immunoglobulin superfamily retinal ganlgion cells Medicine R Science Q Biology (General) QH301-705.5 Pierre-Luc Rochon Catherine Theriault Aline Giselle Rangel Olguin Arjun Krishnaswamy The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| description |
Nearly 50 different mouse retinal ganglion cell (RGC) types sample the visual scene for distinct features. RGC feature selectivity arises from their synapses with a specific subset of amacrine (AC) and bipolar cell (BC) types, but how RGC dendrites arborize and collect input from these specific subsets remains poorly understood. Here we examine the hypothesis that RGCs employ molecular recognition systems to meet this challenge. By combining calcium imaging and type-specific histological stains, we define a family of circuits that express the recognition molecule Sidekick-1 (Sdk1), which include a novel RGC type (S1-RGC) that responds to local edges. Genetic and physiological studies revealed that Sdk1 loss selectively disrupts S1-RGC visual responses, which result from a loss of excitatory and inhibitory inputs and selective dendritic deficits on this neuron. We conclude that Sdk1 shapes dendrite growth and wiring to help S1-RGCs become feature selective. |
| format |
article |
| author |
Pierre-Luc Rochon Catherine Theriault Aline Giselle Rangel Olguin Arjun Krishnaswamy |
| author_facet |
Pierre-Luc Rochon Catherine Theriault Aline Giselle Rangel Olguin Arjun Krishnaswamy |
| author_sort |
Pierre-Luc Rochon |
| title |
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| title_short |
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| title_full |
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| title_fullStr |
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| title_full_unstemmed |
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges |
| title_sort |
cell adhesion molecule sdk1 shapes assembly of a retinal circuit that detects localized edges |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/9c2d1d854d654d6193b4f384be51f90d |
| work_keys_str_mv |
AT pierrelucrochon thecelladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT catherinetheriault thecelladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT alinegisellerangelolguin thecelladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT arjunkrishnaswamy thecelladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT pierrelucrochon celladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT catherinetheriault celladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT alinegisellerangelolguin celladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges AT arjunkrishnaswamy celladhesionmoleculesdk1shapesassemblyofaretinalcircuitthatdetectslocalizededges |
| _version_ |
1718405190141345792 |