Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via cleavage by plasmepsin V.

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Detalles Bibliográficos
Autores principales:	Justin A. Boddey, Matthew T. O’Neill, Sash Lopaticki, Teresa G. Carvalho, Anthony N. Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J. Babon, Alan F. Cowman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c31a074ac774adfad666d242b4d3b61
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spelling	oai:doaj.org-article:9c31a074ac774adfad666d242b4d3b612021-12-02T15:33:49ZExport of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding10.1038/ncomms104702041-1723https://doaj.org/article/9c31a074ac774adfad666d242b4d3b612016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10470https://doaj.org/toc/2041-1723Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via cleavage by plasmepsin V.Justin A. BoddeyMatthew T. O’NeillSash LopatickiTeresa G. CarvalhoAnthony N. HodderThomas NeblStephan WawraPieter van WestZeinab EbrahimzadehDave RichardSven FlemmingTobias SpielmannJude PrzyborskiJeff J. BabonAlan F. CowmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin A. Boddey Matthew T. O’Neill Sash Lopaticki Teresa G. Carvalho Anthony N. Hodder Thomas Nebl Stephan Wawra Pieter van West Zeinab Ebrahimzadeh Dave Richard Sven Flemming Tobias Spielmann Jude Przyborski Jeff J. Babon Alan F. Cowman Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
description	Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via cleavage by plasmepsin V.
format	article
author	Justin A. Boddey Matthew T. O’Neill Sash Lopaticki Teresa G. Carvalho Anthony N. Hodder Thomas Nebl Stephan Wawra Pieter van West Zeinab Ebrahimzadeh Dave Richard Sven Flemming Tobias Spielmann Jude Przyborski Jeff J. Babon Alan F. Cowman
author_facet	Justin A. Boddey Matthew T. O’Neill Sash Lopaticki Teresa G. Carvalho Anthony N. Hodder Thomas Nebl Stephan Wawra Pieter van West Zeinab Ebrahimzadeh Dave Richard Sven Flemming Tobias Spielmann Jude Przyborski Jeff J. Babon Alan F. Cowman
author_sort	Justin A. Boddey
title	Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
title_short	Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
title_full	Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
title_fullStr	Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
title_full_unstemmed	Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
title_sort	export of malaria proteins requires co-translational processing of the pexel motif independent of phosphatidylinositol-3-phosphate binding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9c31a074ac774adfad666d242b4d3b61
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Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

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