Wnt Signaling in Periodontal Disease

Periodontitis is a multifactorial and chronic condition associated with the formation of a dysbiotic biofilm, leading to a pro-inflammatory environment that can modulate cell signaling. The Wnt pathway plays fundamental roles during homeostasis and disease, and emerging evidence suggests its involve...

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Autores principales:	David González-Quintanilla, Nicolás Abásolo, Pablo Astudillo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Wnt pathway periodontal disease periodontitis Wnt5a periodontium inflammation Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/9c35f665765f4ccda34abf647ee1578f
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id	oai:doaj.org-article:9c35f665765f4ccda34abf647ee1578f
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spelling	oai:doaj.org-article:9c35f665765f4ccda34abf647ee1578f2021-11-30T11:58:08ZWnt Signaling in Periodontal Disease2673-491510.3389/fdmed.2021.763308https://doaj.org/article/9c35f665765f4ccda34abf647ee1578f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fdmed.2021.763308/fullhttps://doaj.org/toc/2673-4915Periodontitis is a multifactorial and chronic condition associated with the formation of a dysbiotic biofilm, leading to a pro-inflammatory environment that can modulate cell signaling. The Wnt pathway plays fundamental roles during homeostasis and disease, and emerging evidence suggests its involvement in the maintenance of the periodontium and the development of periodontitis. Here, we summarize the role of the Wnt/β-catenin and non-canonical Wnt signaling pathways in periodontitis. The accumulated data suggests specific roles for each branch of the Wnt pathway. Wnt5a emerges as a critical player promoting periodontal ligament remodeling and impairing regenerative responses modulated by the Wnt/β-catenin pathway, such as alveolar bone formation. Collectively, the evidence suggests that achieving a proper balance between the Wnt/β-catenin and non-canonical pathways, rather than their independent modulation, might contribute to controlling the progression and severity of the periodontal disease.David González-QuintanillaNicolás AbásoloPablo AstudilloFrontiers Media S.A.articleWnt pathwayperiodontal diseaseperiodontitisWnt5aperiodontiuminflammationDentistryRK1-715ENFrontiers in Dental Medicine, Vol 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wnt pathway periodontal disease periodontitis Wnt5a periodontium inflammation Dentistry RK1-715
spellingShingle	Wnt pathway periodontal disease periodontitis Wnt5a periodontium inflammation Dentistry RK1-715 David González-Quintanilla Nicolás Abásolo Pablo Astudillo Wnt Signaling in Periodontal Disease
description	Periodontitis is a multifactorial and chronic condition associated with the formation of a dysbiotic biofilm, leading to a pro-inflammatory environment that can modulate cell signaling. The Wnt pathway plays fundamental roles during homeostasis and disease, and emerging evidence suggests its involvement in the maintenance of the periodontium and the development of periodontitis. Here, we summarize the role of the Wnt/β-catenin and non-canonical Wnt signaling pathways in periodontitis. The accumulated data suggests specific roles for each branch of the Wnt pathway. Wnt5a emerges as a critical player promoting periodontal ligament remodeling and impairing regenerative responses modulated by the Wnt/β-catenin pathway, such as alveolar bone formation. Collectively, the evidence suggests that achieving a proper balance between the Wnt/β-catenin and non-canonical pathways, rather than their independent modulation, might contribute to controlling the progression and severity of the periodontal disease.
format	article
author	David González-Quintanilla Nicolás Abásolo Pablo Astudillo
author_facet	David González-Quintanilla Nicolás Abásolo Pablo Astudillo
author_sort	David González-Quintanilla
title	Wnt Signaling in Periodontal Disease
title_short	Wnt Signaling in Periodontal Disease
title_full	Wnt Signaling in Periodontal Disease
title_fullStr	Wnt Signaling in Periodontal Disease
title_full_unstemmed	Wnt Signaling in Periodontal Disease
title_sort	wnt signaling in periodontal disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9c35f665765f4ccda34abf647ee1578f
work_keys_str_mv	AT davidgonzalezquintanilla wntsignalinginperiodontaldisease AT nicolasabasolo wntsignalinginperiodontaldisease AT pabloastudillo wntsignalinginperiodontaldisease
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Wnt Signaling in Periodontal Disease

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