Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas

Head and neck squamous cell carcinomas (HNSCC) are common tumors with a poor overall prognosis. Poor survival is resulting from limited response to multi-modal therapy, high incidence of metastasis, and local recurrence. Treatment includes surgery, radio(chemo)therapy, and targeted therapy specific...

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Autores principales:	Philipp Baumeister, Jiefu Zhou, Martin Canis, Olivier Gires
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	head and neck squamous cell carcinoma (partial) epithelial-to-mesenchymal transition therapy resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9c36456f36da4f6594369b9581000e31
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spelling	oai:doaj.org-article:9c36456f36da4f6594369b9581000e312021-11-11T15:28:55ZEpithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas10.3390/cancers132153552072-6694https://doaj.org/article/9c36456f36da4f6594369b9581000e312021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5355https://doaj.org/toc/2072-6694Head and neck squamous cell carcinomas (HNSCC) are common tumors with a poor overall prognosis. Poor survival is resulting from limited response to multi-modal therapy, high incidence of metastasis, and local recurrence. Treatment includes surgery, radio(chemo)therapy, and targeted therapy specific for EGFR and immune checkpoint inhibition. The understanding of the molecular basis for the poor outcome of HNSCC was improved using multi-OMICs approaches, which revealed a strong degree of inter- and intratumor heterogeneity (ITH) at the level of DNA mutations, transcriptome, and (phospho)proteome. Single-cell RNA-sequencing (scRNA-seq) identified RNA-expression signatures related to cell cycle, cell stress, hypoxia, epithelial differentiation, and a partial epithelial-to-mesenchymal transition (pEMT). The latter signature was correlated to nodal involvement and adverse clinical features. Mechanistically, shifts towards a mesenchymal phenotype equips tumor cells with migratory and invasive capacities and with an enhanced resistance to standard therapy. Hence, gradual variations of EMT as observed in HNSCC represent a potent driver of tumor progression that could open new paths to improve the stratification of patients and to innovate approaches to break therapy resistance. These aspects of molecular heterogeneity will be discussed in the present review.Philipp BaumeisterJiefu ZhouMartin CanisOlivier GiresMDPI AGarticlehead and neck squamous cell carcinoma(partial) epithelial-to-mesenchymal transitiontherapy resistanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5355, p 5355 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck squamous cell carcinoma (partial) epithelial-to-mesenchymal transition therapy resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	head and neck squamous cell carcinoma (partial) epithelial-to-mesenchymal transition therapy resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Philipp Baumeister Jiefu Zhou Martin Canis Olivier Gires Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
description	Head and neck squamous cell carcinomas (HNSCC) are common tumors with a poor overall prognosis. Poor survival is resulting from limited response to multi-modal therapy, high incidence of metastasis, and local recurrence. Treatment includes surgery, radio(chemo)therapy, and targeted therapy specific for EGFR and immune checkpoint inhibition. The understanding of the molecular basis for the poor outcome of HNSCC was improved using multi-OMICs approaches, which revealed a strong degree of inter- and intratumor heterogeneity (ITH) at the level of DNA mutations, transcriptome, and (phospho)proteome. Single-cell RNA-sequencing (scRNA-seq) identified RNA-expression signatures related to cell cycle, cell stress, hypoxia, epithelial differentiation, and a partial epithelial-to-mesenchymal transition (pEMT). The latter signature was correlated to nodal involvement and adverse clinical features. Mechanistically, shifts towards a mesenchymal phenotype equips tumor cells with migratory and invasive capacities and with an enhanced resistance to standard therapy. Hence, gradual variations of EMT as observed in HNSCC represent a potent driver of tumor progression that could open new paths to improve the stratification of patients and to innovate approaches to break therapy resistance. These aspects of molecular heterogeneity will be discussed in the present review.
format	article
author	Philipp Baumeister Jiefu Zhou Martin Canis Olivier Gires
author_facet	Philipp Baumeister Jiefu Zhou Martin Canis Olivier Gires
author_sort	Philipp Baumeister
title	Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
title_short	Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
title_full	Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
title_fullStr	Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
title_full_unstemmed	Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
title_sort	epithelial-to-mesenchymal transition-derived heterogeneity in head and neck squamous cell carcinomas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9c36456f36da4f6594369b9581000e31
work_keys_str_mv	AT philippbaumeister epithelialtomesenchymaltransitionderivedheterogeneityinheadandnecksquamouscellcarcinomas AT jiefuzhou epithelialtomesenchymaltransitionderivedheterogeneityinheadandnecksquamouscellcarcinomas AT martincanis epithelialtomesenchymaltransitionderivedheterogeneityinheadandnecksquamouscellcarcinomas AT oliviergires epithelialtomesenchymaltransitionderivedheterogeneityinheadandnecksquamouscellcarcinomas
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Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas

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