Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer

Abstract Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-dept...

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Autores principales:	Ji Young Kim, Hyebin Lee, Jongmin Woo, Wang Yue, Kwangsoo Kim, Seongmin Choi, Ja-June Jang, Youngsoo Kim, In Ae Park, Dohyun Han, Han Suk Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c37b2e0b7134150881904106462bd3e
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spelling	oai:doaj.org-article:9c37b2e0b7134150881904106462bd3e2021-12-02T11:53:10ZReconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer10.1038/s41598-017-03322-72045-2322https://doaj.org/article/9c37b2e0b7134150881904106462bd3e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03322-7https://doaj.org/toc/2045-2322Abstract Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-depth proteomic analyses to characterize the network of molecular interactions in TNBC cells treated with nicotinamide. The multi-omic profiles revealed that nicotinamide drives significant functional alterations related to major cellular pathways, including the cell cycle, DNA replication, apoptosis and DNA damage repair. We further elaborated the global interaction networks of molecular events via nicotinamide-inducible expression changes at the mRNA and functional protein levels. This approach indicated that nicotinamide treatment rewires interaction networks toward dysfunction in DNA damage repair and away from a pro-growth state in TNBC. To our knowledge, the high-resolution network interactions identified in the present study provide the first evidence to comprehensively support the hypothesis of nicotinamide as a novel therapeutic agent in TNBC.Ji Young KimHyebin LeeJongmin WooWang YueKwangsoo KimSeongmin ChoiJa-June JangYoungsoo KimIn Ae ParkDohyun HanHan Suk RyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Young Kim Hyebin Lee Jongmin Woo Wang Yue Kwangsoo Kim Seongmin Choi Ja-June Jang Youngsoo Kim In Ae Park Dohyun Han Han Suk Ryu Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
description	Abstract Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-depth proteomic analyses to characterize the network of molecular interactions in TNBC cells treated with nicotinamide. The multi-omic profiles revealed that nicotinamide drives significant functional alterations related to major cellular pathways, including the cell cycle, DNA replication, apoptosis and DNA damage repair. We further elaborated the global interaction networks of molecular events via nicotinamide-inducible expression changes at the mRNA and functional protein levels. This approach indicated that nicotinamide treatment rewires interaction networks toward dysfunction in DNA damage repair and away from a pro-growth state in TNBC. To our knowledge, the high-resolution network interactions identified in the present study provide the first evidence to comprehensively support the hypothesis of nicotinamide as a novel therapeutic agent in TNBC.
format	article
author	Ji Young Kim Hyebin Lee Jongmin Woo Wang Yue Kwangsoo Kim Seongmin Choi Ja-June Jang Youngsoo Kim In Ae Park Dohyun Han Han Suk Ryu
author_facet	Ji Young Kim Hyebin Lee Jongmin Woo Wang Yue Kwangsoo Kim Seongmin Choi Ja-June Jang Youngsoo Kim In Ae Park Dohyun Han Han Suk Ryu
author_sort	Ji Young Kim
title	Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
title_short	Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
title_full	Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
title_fullStr	Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
title_full_unstemmed	Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
title_sort	reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c37b2e0b7134150881904106462bd3e
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Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer

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