Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species

Abstract The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMP...

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Autores principales: Anouk Lepez, Tiphène Pirnay, Sébastien Denanglaire, David Perez-Morga, Marjorie Vermeersch, Oberdan Leo, Fabienne Andris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9c385a8aea9048439529ca4cda5d6ca6
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