Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.

<h4>Introduction</h4>Biliary complications following liver transplantation are common. The effect of intraoperative fluid balance and vasopressors on these complications is unknown.<h4>Materials and methods</h4>We conducted a cohort study between July 2008 and December 2017....

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Autores principales:	Jordan Larivière, Jeanne-Marie Giard, Rui Min Zuo, Luc Massicotte, Michaël Chassé, François Martin Carrier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c3908d6e26c4a10bcecae52326f58a7
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spelling	oai:doaj.org-article:9c3908d6e26c4a10bcecae52326f58a72021-12-02T20:15:30ZAssociation between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.1932-620310.1371/journal.pone.0254455https://doaj.org/article/9c3908d6e26c4a10bcecae52326f58a72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254455https://doaj.org/toc/1932-6203<h4>Introduction</h4>Biliary complications following liver transplantation are common. The effect of intraoperative fluid balance and vasopressors on these complications is unknown.<h4>Materials and methods</h4>We conducted a cohort study between July 2008 and December 2017. Our exposure variables were the total intraoperative fluid balance and the use of vasopressors on ICU admission. Our primary outcome was any biliary complication (anastomotic and non-anastomotic strictures) up to one year after transplantation. Our secondary outcomes were vascular complications, primary graft non-function and survival.<h4>Results</h4>We included 562 consecutive liver transplantations. 192 (34%) transplants had a biliary complication, 167 (30%) had an anastomotic stricture and 56 had a non-anastomotic stricture (10%). We did not observe any effect of intraoperative fluid balance or vasopressor on biliary complications (HR = 0.97; 95% CI, 0.93 to 1.02). A higher intraoperative fluid balance was associated with an increased risk of primary graft non-function (non-linear) and a lower survival (HR = 1.40, 95% CI, 1.14 to 1.71) in multivariable analyses.<h4>Conclusion</h4>Intraoperative fluid balance and vasopressors upon ICU admission were not associated with biliary complications after liver transplantation but may be associated with other adverse events. Intraoperative hemodynamic management must be prospectively studied to further assess their impact on liver recipients' outcomes.Jordan LarivièreJeanne-Marie GiardRui Min ZuoLuc MassicotteMichaël ChasséFrançois Martin CarrierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jordan Larivière Jeanne-Marie Giard Rui Min Zuo Luc Massicotte Michaël Chassé François Martin Carrier Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
description	<h4>Introduction</h4>Biliary complications following liver transplantation are common. The effect of intraoperative fluid balance and vasopressors on these complications is unknown.<h4>Materials and methods</h4>We conducted a cohort study between July 2008 and December 2017. Our exposure variables were the total intraoperative fluid balance and the use of vasopressors on ICU admission. Our primary outcome was any biliary complication (anastomotic and non-anastomotic strictures) up to one year after transplantation. Our secondary outcomes were vascular complications, primary graft non-function and survival.<h4>Results</h4>We included 562 consecutive liver transplantations. 192 (34%) transplants had a biliary complication, 167 (30%) had an anastomotic stricture and 56 had a non-anastomotic stricture (10%). We did not observe any effect of intraoperative fluid balance or vasopressor on biliary complications (HR = 0.97; 95% CI, 0.93 to 1.02). A higher intraoperative fluid balance was associated with an increased risk of primary graft non-function (non-linear) and a lower survival (HR = 1.40, 95% CI, 1.14 to 1.71) in multivariable analyses.<h4>Conclusion</h4>Intraoperative fluid balance and vasopressors upon ICU admission were not associated with biliary complications after liver transplantation but may be associated with other adverse events. Intraoperative hemodynamic management must be prospectively studied to further assess their impact on liver recipients' outcomes.
format	article
author	Jordan Larivière Jeanne-Marie Giard Rui Min Zuo Luc Massicotte Michaël Chassé François Martin Carrier
author_facet	Jordan Larivière Jeanne-Marie Giard Rui Min Zuo Luc Massicotte Michaël Chassé François Martin Carrier
author_sort	Jordan Larivière
title	Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
title_short	Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
title_full	Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
title_fullStr	Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
title_full_unstemmed	Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.
title_sort	association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: a cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9c3908d6e26c4a10bcecae52326f58a7
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Association between intraoperative fluid balance, vasopressors and graft complications in liver transplantation: A cohort study.

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