Insulin resistance in pathogenesis of type 2 diabetes mellitus

This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor le...

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Autor principal:	Alexander Yur'evich Mayorov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	insulin resistance type 2 diabetes mellitus glucose utilization in tissues m-index disturbed fasting glycemia impaired glucose tolerance Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/9c40cd270214469baf7a8e1f2b6164f3
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spelling	oai:doaj.org-article:9c40cd270214469baf7a8e1f2b6164f32021-11-14T09:00:15ZInsulin resistance in pathogenesis of type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-6248https://doaj.org/article/9c40cd270214469baf7a8e1f2b6164f32011-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6248https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed.Alexander Yur'evich MayorovEndocrinology Research Centrearticleinsulin resistancetype 2 diabetes mellitusglucose utilization in tissuesm-indexdisturbed fasting glycemiaimpaired glucose toleranceNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 1, Pp 35-45 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	insulin resistance type 2 diabetes mellitus glucose utilization in tissues m-index disturbed fasting glycemia impaired glucose tolerance Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	insulin resistance type 2 diabetes mellitus glucose utilization in tissues m-index disturbed fasting glycemia impaired glucose tolerance Nutritional diseases. Deficiency diseases RC620-627 Alexander Yur'evich Mayorov Insulin resistance in pathogenesis of type 2 diabetes mellitus
description	This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed.
format	article
author	Alexander Yur'evich Mayorov
author_facet	Alexander Yur'evich Mayorov
author_sort	Alexander Yur'evich Mayorov
title	Insulin resistance in pathogenesis of type 2 diabetes mellitus
title_short	Insulin resistance in pathogenesis of type 2 diabetes mellitus
title_full	Insulin resistance in pathogenesis of type 2 diabetes mellitus
title_fullStr	Insulin resistance in pathogenesis of type 2 diabetes mellitus
title_full_unstemmed	Insulin resistance in pathogenesis of type 2 diabetes mellitus
title_sort	insulin resistance in pathogenesis of type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/9c40cd270214469baf7a8e1f2b6164f3
work_keys_str_mv	AT alexanderyurevichmayorov insulinresistanceinpathogenesisoftype2diabetesmellitus
_version_	1718429597980164096

Insulin resistance in pathogenesis of type 2 diabetes mellitus

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