DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c453a3351fb46c1bf8f6e6f7cadf691
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c453a3351fb46c1bf8f6e6f7cadf691
record_format	dspace
spelling	oai:doaj.org-article:9c453a3351fb46c1bf8f6e6f7cadf6912021-12-02T14:39:00ZDRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass10.1038/s41467-019-10226-92041-1723https://doaj.org/article/9c453a3351fb46c1bf8f6e6f7cadf6912019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10226-9https://doaj.org/toc/2041-1723Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy by altering Ca2+ homeostasis and cellular stress responses.Giulia FavaroVanina RomanelloTatiana VaranitaMaria Andrea DesbatsValeria MorbidoniCaterina TezzeMattia AlbieroMarta CanatoGaia GherardiDiego De StefaniCristina MammucariBert BlaauwSimona BoncompagniFeliciano ProtasiCarlo ReggianiLuca ScorranoLeonardo SalviatiMarco SandriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Favaro Vanina Romanello Tatiana Varanita Maria Andrea Desbats Valeria Morbidoni Caterina Tezze Mattia Albiero Marta Canato Gaia Gherardi Diego De Stefani Cristina Mammucari Bert Blaauw Simona Boncompagni Feliciano Protasi Carlo Reggiani Luca Scorrano Leonardo Salviati Marco Sandri DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
description	Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy by altering Ca2+ homeostasis and cellular stress responses.
format	article
author	Giulia Favaro Vanina Romanello Tatiana Varanita Maria Andrea Desbats Valeria Morbidoni Caterina Tezze Mattia Albiero Marta Canato Gaia Gherardi Diego De Stefani Cristina Mammucari Bert Blaauw Simona Boncompagni Feliciano Protasi Carlo Reggiani Luca Scorrano Leonardo Salviati Marco Sandri
author_facet	Giulia Favaro Vanina Romanello Tatiana Varanita Maria Andrea Desbats Valeria Morbidoni Caterina Tezze Mattia Albiero Marta Canato Gaia Gherardi Diego De Stefani Cristina Mammucari Bert Blaauw Simona Boncompagni Feliciano Protasi Carlo Reggiani Luca Scorrano Leonardo Salviati Marco Sandri
author_sort	Giulia Favaro
title	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
title_short	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
title_full	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
title_fullStr	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
title_full_unstemmed	DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
title_sort	drp1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c453a3351fb46c1bf8f6e6f7cadf691
work_keys_str_mv	AT giuliafavaro drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT vaninaromanello drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT tatianavaranita drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT mariaandreadesbats drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT valeriamorbidoni drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT caterinatezze drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT mattiaalbiero drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT martacanato drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT gaiagherardi drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT diegodestefani drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT cristinamammucari drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT bertblaauw drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT simonaboncompagni drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT felicianoprotasi drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT carloreggiani drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT lucascorrano drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT leonardosalviati drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass AT marcosandri drp1mediatedmitochondrialshapecontrolscalciumhomeostasisandmusclemass
_version_	1718390786600468480

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

Ejemplares similares