Dual role of miR-21 in CD4+ T-cells: activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells.

Dual role of miR-21 in CD4+ T-cells: activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells.

Immune cell-type specific miRNA expression patterns have been described but the detailed role of single miRNAs in the function of T-cells remains largely unknown. We investigated the role of miR-21 in the function of primary human CD4+ T-cells. MiR-21 is substantially expressed in T-cells with a mem...

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Autores principales: Katarzyna Smigielska-Czepiel, Anke van den Berg, Pytrick Jellema, Izabella Slezak-Prochazka, Henny Maat, Hilda van den Bos, Roelof Jan van der Lei, Joost Kluiver, Elisabeth Brouwer, Anne Mieke H Boots, Bart-Jan Kroesen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9c4620931b814e8f846ba8cf27b8db52
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