Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation

Non-coding RNAs have been shown to be key components in translational regulation. Here the authors characterize long nucleolus specific lncRNA termed LoNA, identified to play a role in protein biosynthesis by inhibiting rRNA production and ribosome biosynthesis in nucleoli.

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Detalles Bibliográficos
Autores principales: Dingfeng Li, Juan Zhang, Ming Wang, Xiaohui Li, Huarui Gong, Huiping Tang, Lin Chen, Lili Wan, Qiang Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9c46dff0d82944de8252c3ecb5fd350c
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Sumario:Non-coding RNAs have been shown to be key components in translational regulation. Here the authors characterize long nucleolus specific lncRNA termed LoNA, identified to play a role in protein biosynthesis by inhibiting rRNA production and ribosome biosynthesis in nucleoli.