Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy
Epigenetic regulation involves reversible changes in histones and DNA modifications that can be inherited without any changes in the DNA sequence. Dysregulation of normal epigenetic processes can lead to aberrant gene expression as observed in many diseases, notably cancer. Recent insights into the...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:9c49d876f7f842eea1ba5c5a9062dc932021-11-09T06:14:06ZRole of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy1664-802110.3389/fgene.2021.758733https://doaj.org/article/9c49d876f7f842eea1ba5c5a9062dc932021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.758733/fullhttps://doaj.org/toc/1664-8021Epigenetic regulation involves reversible changes in histones and DNA modifications that can be inherited without any changes in the DNA sequence. Dysregulation of normal epigenetic processes can lead to aberrant gene expression as observed in many diseases, notably cancer. Recent insights into the mechanisms of DNA methylation, histone modifications, and non-coding RNAs involved in altered gene expression profiles of tumor cells have caused a paradigm shift in the diagnostic and therapeutic approaches towards cancer. There has been a surge in search for compounds that could modulate the altered epigenetic landscape of tumor cells, and to exploit their therapeutic potential against cancers. Flavonoids are naturally occurring phenol compounds which are abundantly found among phytochemicals and have potentials to modulate epigenetic processes. Knowledge of the precise flavonoid-mediated epigenetic alterations is needed for the development of epigenetics drugs and combinatorial therapeutic approaches against cancers. This review is aimed to comprehensively explore the epigenetic modulations of flavonoids and their anti-tumor activities.Nishat FatimaSyed Shabihe Raza BaqriAtrayee BhattacharyaNii Koney-Kwaku KoneyKazim HusainAta AbbasAta AbbasRais A. AnsariFrontiers Media S.A.articlecancerflavonoidsepigeneticsDNA methylationhistone modificationsnon-coding RNAsGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
cancer flavonoids epigenetics DNA methylation histone modifications non-coding RNAs Genetics QH426-470 |
| spellingShingle |
cancer flavonoids epigenetics DNA methylation histone modifications non-coding RNAs Genetics QH426-470 Nishat Fatima Syed Shabihe Raza Baqri Atrayee Bhattacharya Nii Koney-Kwaku Koney Kazim Husain Ata Abbas Ata Abbas Rais A. Ansari Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| description |
Epigenetic regulation involves reversible changes in histones and DNA modifications that can be inherited without any changes in the DNA sequence. Dysregulation of normal epigenetic processes can lead to aberrant gene expression as observed in many diseases, notably cancer. Recent insights into the mechanisms of DNA methylation, histone modifications, and non-coding RNAs involved in altered gene expression profiles of tumor cells have caused a paradigm shift in the diagnostic and therapeutic approaches towards cancer. There has been a surge in search for compounds that could modulate the altered epigenetic landscape of tumor cells, and to exploit their therapeutic potential against cancers. Flavonoids are naturally occurring phenol compounds which are abundantly found among phytochemicals and have potentials to modulate epigenetic processes. Knowledge of the precise flavonoid-mediated epigenetic alterations is needed for the development of epigenetics drugs and combinatorial therapeutic approaches against cancers. This review is aimed to comprehensively explore the epigenetic modulations of flavonoids and their anti-tumor activities. |
| format |
article |
| author |
Nishat Fatima Syed Shabihe Raza Baqri Atrayee Bhattacharya Nii Koney-Kwaku Koney Kazim Husain Ata Abbas Ata Abbas Rais A. Ansari |
| author_facet |
Nishat Fatima Syed Shabihe Raza Baqri Atrayee Bhattacharya Nii Koney-Kwaku Koney Kazim Husain Ata Abbas Ata Abbas Rais A. Ansari |
| author_sort |
Nishat Fatima |
| title |
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| title_short |
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| title_full |
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| title_fullStr |
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| title_full_unstemmed |
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy |
| title_sort |
role of flavonoids as epigenetic modulators in cancer prevention and therapy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9c49d876f7f842eea1ba5c5a9062dc93 |
| work_keys_str_mv |
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