Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice

Abstract Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother’s milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma O...

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Autores principales:	Haruhiro Higashida, Kazumi Furuhara, Agnes-Mikiko Yamauchi, Kisaburo Deguchi, Ai Harashima, Seiichi Munesue, Olga Lopatina, Maria Gerasimenko, Alla B. Salmina, Jia-Sheng Zhang, Hikari Kodama, Hironori Kuroda, Chiharu Tsuji, Satoshi Suto, Hiroshi Yamamoto, Yasuhiko Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c5109bcaf4d4ec0aa924639ce7f395d
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spelling	oai:doaj.org-article:9c5109bcaf4d4ec0aa924639ce7f395d2021-12-02T12:30:34ZIntestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice10.1038/s41598-017-07949-42045-2322https://doaj.org/article/9c5109bcaf4d4ec0aa924639ce7f395d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07949-4https://doaj.org/toc/2045-2322Abstract Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother’s milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1–7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed. In adult mice, plasma OT was also increased in a RAGE-dependent manner after oral delivery or direct administration into the intestinal tract. Mass spectrometry evaluated that OT was absorbed intact. RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults. These data highlight that OT is transmitted via a receptor-mediated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug development.Haruhiro HigashidaKazumi FuruharaAgnes-Mikiko YamauchiKisaburo DeguchiAi HarashimaSeiichi MunesueOlga LopatinaMaria GerasimenkoAlla B. SalminaJia-Sheng ZhangHikari KodamaHironori KurodaChiharu TsujiSatoshi SutoHiroshi YamamotoYasuhiko YamamotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haruhiro Higashida Kazumi Furuhara Agnes-Mikiko Yamauchi Kisaburo Deguchi Ai Harashima Seiichi Munesue Olga Lopatina Maria Gerasimenko Alla B. Salmina Jia-Sheng Zhang Hikari Kodama Hironori Kuroda Chiharu Tsuji Satoshi Suto Hiroshi Yamamoto Yasuhiko Yamamoto Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
description	Abstract Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother’s milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1–7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed. In adult mice, plasma OT was also increased in a RAGE-dependent manner after oral delivery or direct administration into the intestinal tract. Mass spectrometry evaluated that OT was absorbed intact. RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults. These data highlight that OT is transmitted via a receptor-mediated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug development.
format	article
author	Haruhiro Higashida Kazumi Furuhara Agnes-Mikiko Yamauchi Kisaburo Deguchi Ai Harashima Seiichi Munesue Olga Lopatina Maria Gerasimenko Alla B. Salmina Jia-Sheng Zhang Hikari Kodama Hironori Kuroda Chiharu Tsuji Satoshi Suto Hiroshi Yamamoto Yasuhiko Yamamoto
author_facet	Haruhiro Higashida Kazumi Furuhara Agnes-Mikiko Yamauchi Kisaburo Deguchi Ai Harashima Seiichi Munesue Olga Lopatina Maria Gerasimenko Alla B. Salmina Jia-Sheng Zhang Hikari Kodama Hironori Kuroda Chiharu Tsuji Satoshi Suto Hiroshi Yamamoto Yasuhiko Yamamoto
author_sort	Haruhiro Higashida
title	Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
title_short	Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
title_full	Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
title_fullStr	Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
title_full_unstemmed	Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
title_sort	intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c5109bcaf4d4ec0aa924639ce7f395d
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Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice

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