Role of p66shc in skeletal muscle function

Abstract p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS production. p66shc is involved in insulin signaling and its deletion exerts a protective effect against diet-induced obesity. In light of the role of skeletal muscle activity in the control of systemic metabolis...

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Autores principales:	Veronica Granatiero, Gaia Gherardi, Matteo Vianello, Elsa Salerno, Erika Zecchini, Luana Toniolo, Giorgia Pallafacchina, Marta Murgia, Bert Blaauw, Rosario Rizzuto, Cristina Mammucari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c51b3a338f34fd1b0c6da1ace4719f6
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spelling	oai:doaj.org-article:9c51b3a338f34fd1b0c6da1ace4719f62021-12-02T11:40:23ZRole of p66shc in skeletal muscle function10.1038/s41598-017-06363-02045-2322https://doaj.org/article/9c51b3a338f34fd1b0c6da1ace4719f62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06363-0https://doaj.org/toc/2045-2322Abstract p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS production. p66shc is involved in insulin signaling and its deletion exerts a protective effect against diet-induced obesity. In light of the role of skeletal muscle activity in the control of systemic metabolism and obesity, we investigated which is the contribution of p66shc in regulating muscle structure and function. Here, we show that p66shc−/− muscles are undistinguishable from controls in terms of size, resistance to denervation-induced atrophy, and force. However, p66shc−/− mice perform slightly better than wild type animals during repetitive downhill running. Analysis of the effects after placing mice on a high fat diet (HFD) regimen demonstrated that running distance is greatly reduced in obese wild type animals, but not in overweight-resistant p66shc−/− mice. In addition, muscle force measured after exercise decreases upon HFD in wild type mice while p66shc−/− animals are protected. Our data indicate that p66shc affect the response to damage of adult muscle in chow diet, and it determines the maintenance of muscle force and exercise performance upon a HFD regimen.Veronica GranatieroGaia GherardiMatteo VianelloElsa SalernoErika ZecchiniLuana TonioloGiorgia PallafacchinaMarta MurgiaBert BlaauwRosario RizzutoCristina MammucariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Veronica Granatiero Gaia Gherardi Matteo Vianello Elsa Salerno Erika Zecchini Luana Toniolo Giorgia Pallafacchina Marta Murgia Bert Blaauw Rosario Rizzuto Cristina Mammucari Role of p66shc in skeletal muscle function
description	Abstract p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS production. p66shc is involved in insulin signaling and its deletion exerts a protective effect against diet-induced obesity. In light of the role of skeletal muscle activity in the control of systemic metabolism and obesity, we investigated which is the contribution of p66shc in regulating muscle structure and function. Here, we show that p66shc−/− muscles are undistinguishable from controls in terms of size, resistance to denervation-induced atrophy, and force. However, p66shc−/− mice perform slightly better than wild type animals during repetitive downhill running. Analysis of the effects after placing mice on a high fat diet (HFD) regimen demonstrated that running distance is greatly reduced in obese wild type animals, but not in overweight-resistant p66shc−/− mice. In addition, muscle force measured after exercise decreases upon HFD in wild type mice while p66shc−/− animals are protected. Our data indicate that p66shc affect the response to damage of adult muscle in chow diet, and it determines the maintenance of muscle force and exercise performance upon a HFD regimen.
format	article
author	Veronica Granatiero Gaia Gherardi Matteo Vianello Elsa Salerno Erika Zecchini Luana Toniolo Giorgia Pallafacchina Marta Murgia Bert Blaauw Rosario Rizzuto Cristina Mammucari
author_facet	Veronica Granatiero Gaia Gherardi Matteo Vianello Elsa Salerno Erika Zecchini Luana Toniolo Giorgia Pallafacchina Marta Murgia Bert Blaauw Rosario Rizzuto Cristina Mammucari
author_sort	Veronica Granatiero
title	Role of p66shc in skeletal muscle function
title_short	Role of p66shc in skeletal muscle function
title_full	Role of p66shc in skeletal muscle function
title_fullStr	Role of p66shc in skeletal muscle function
title_full_unstemmed	Role of p66shc in skeletal muscle function
title_sort	role of p66shc in skeletal muscle function
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c51b3a338f34fd1b0c6da1ace4719f6
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Role of p66shc in skeletal muscle function

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