PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA

Abstract. The aim of the study was to assess prevalence and risk factors for cryoglobulinemia associated with chronic hepatitis C in St.-Petersburg. Patients and methods. We studied 121 patients with chronic hepatitis C, including 53 men and 68 women with median age of 39±13 years. The median hepati...

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Autores principales:	N. V. Dunaeva, Yu. A. Neustroeva, T. A. Tikhomirova, K. A. Syssoev, N. P. Alexeeva, S. V. Lapin, E. V. Esaulenko, V. A. Dobronravov, A. B. Chukhlovin, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic hepatitis c cryoglobulinemia risk factors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9c546d49cd1a4d76b86ff5d2718614c6
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spelling	oai:doaj.org-article:9c546d49cd1a4d76b86ff5d2718614c62021-11-18T08:03:38ZPREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA1563-06252313-741X10.15789/1563-0625-2007-6-575-580https://doaj.org/article/9c546d49cd1a4d76b86ff5d2718614c62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/243https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of the study was to assess prevalence and risk factors for cryoglobulinemia associated with chronic hepatitis C in St.-Petersburg. Patients and methods. We studied 121 patients with chronic hepatitis C, including 53 men and 68 women with median age of 39±13 years. The median hepatitis duration was 3 years (range 0.5 to 34 years). In this group 25 (20,7%) had cirrhosis. Results. 37,2% (45/121) patients had circulating cryoglobulins. A low levels of crioglobulins (cryocrit 1-4%) were detected more frequently. Cryoglobulinaemic patients showed more frequent rates rheumatoid factors activity (р = 0,001), a higher levels of bilirubin (р = 0,003) and a γ-gamma-glutamyltransferase (р = 0,031). The presence of cryoglobulins was not correlated with HCV genotype (HCV 1a – 20,8% vs 20,7%, 1b – 29,2% vs 27,6%, 2 – 4,2% vs 6,9%, 3a – 20,8 vs 34,5%, mixt – 20,8% vs 6,9%, not identified – 4,1% vs 3,4%, in cryopositive vs cryonegative patients respectively, р = 0,7). By multivariate analysis hepatitis duration (Exp (B) = 1,07, 95% Cl 1,0-1,13, р = 0,049) and cirrhosis (Exp (B) = 6,2, 95% Cl 2,25-16,8, р < 0,001) could independently predict the presence of cryoglobulins. Conclusion. Our study demonstrates high prevalence of serum cryoglobulins in patients with chronic hepatitis C in St.-Petersburg and independent association between duration of hepatitis and advanced cirrhosis with development of cryoglobulinemia.N. V. DunaevaYu. A. NeustroevaT. A. TikhomirovaK. A. SyssoevN. P. AlexeevaS. V. LapinE. V. EsaulenkoV. A. DobronravovA. B. ChukhlovinAreg A. TotolianSPb RAACIarticlechronic hepatitis ccryoglobulinemiarisk factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 6, Pp 575-580 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic hepatitis c cryoglobulinemia risk factors Immunologic diseases. Allergy RC581-607
spellingShingle	chronic hepatitis c cryoglobulinemia risk factors Immunologic diseases. Allergy RC581-607 N. V. Dunaeva Yu. A. Neustroeva T. A. Tikhomirova K. A. Syssoev N. P. Alexeeva S. V. Lapin E. V. Esaulenko V. A. Dobronravov A. B. Chukhlovin Areg A. Totolian PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
description	Abstract. The aim of the study was to assess prevalence and risk factors for cryoglobulinemia associated with chronic hepatitis C in St.-Petersburg. Patients and methods. We studied 121 patients with chronic hepatitis C, including 53 men and 68 women with median age of 39±13 years. The median hepatitis duration was 3 years (range 0.5 to 34 years). In this group 25 (20,7%) had cirrhosis. Results. 37,2% (45/121) patients had circulating cryoglobulins. A low levels of crioglobulins (cryocrit 1-4%) were detected more frequently. Cryoglobulinaemic patients showed more frequent rates rheumatoid factors activity (р = 0,001), a higher levels of bilirubin (р = 0,003) and a γ-gamma-glutamyltransferase (р = 0,031). The presence of cryoglobulins was not correlated with HCV genotype (HCV 1a – 20,8% vs 20,7%, 1b – 29,2% vs 27,6%, 2 – 4,2% vs 6,9%, 3a – 20,8 vs 34,5%, mixt – 20,8% vs 6,9%, not identified – 4,1% vs 3,4%, in cryopositive vs cryonegative patients respectively, р = 0,7). By multivariate analysis hepatitis duration (Exp (B) = 1,07, 95% Cl 1,0-1,13, р = 0,049) and cirrhosis (Exp (B) = 6,2, 95% Cl 2,25-16,8, р < 0,001) could independently predict the presence of cryoglobulins. Conclusion. Our study demonstrates high prevalence of serum cryoglobulins in patients with chronic hepatitis C in St.-Petersburg and independent association between duration of hepatitis and advanced cirrhosis with development of cryoglobulinemia.
format	article
author	N. V. Dunaeva Yu. A. Neustroeva T. A. Tikhomirova K. A. Syssoev N. P. Alexeeva S. V. Lapin E. V. Esaulenko V. A. Dobronravov A. B. Chukhlovin Areg A. Totolian
author_facet	N. V. Dunaeva Yu. A. Neustroeva T. A. Tikhomirova K. A. Syssoev N. P. Alexeeva S. V. Lapin E. V. Esaulenko V. A. Dobronravov A. B. Chukhlovin Areg A. Totolian
author_sort	N. V. Dunaeva
title	PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
title_short	PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
title_full	PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
title_fullStr	PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
title_full_unstemmed	PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA
title_sort	prevalence and risk factors in development of chronic hepatitis c-associated cryoglobulinemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9c546d49cd1a4d76b86ff5d2718614c6
work_keys_str_mv	AT nvdunaeva prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT yuaneustroeva prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT tatikhomirova prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT kasyssoev prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT npalexeeva prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT svlapin prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT evesaulenko prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT vadobronravov prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT abchukhlovin prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia AT aregatotolian prevalenceandriskfactorsindevelopmentofchronichepatitiscassociatedcryoglobulinemia
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PREVALENCE AND RISK FACTORS IN DEVELOPMENT OF CHRONIC HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA

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