Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to <italic toggle="yes">Clostridium difficile</italic> Virulence

Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to <italic toggle="yes">Clostridium difficile</italic> Virulence

ABSTRACT Clostridium difficile is a spore-forming anaerobic bacterium that causes colitis in patients with disrupted colonic microbiota. While some individuals are asymptomatic C. difficile carriers, symptomatic disease ranges from mild diarrhea to potentially lethal toxic megacolon. The wide diseas...

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Autores principales: Brittany B. Lewis, Rebecca A. Carter, Lilan Ling, Ingrid Leiner, Ying Taur, Mini Kamboj, Erik R. Dubberke, Joao Xavier, Eric G. Pamer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Clostridium difficile
accessory genome
bile salt
genome analysis
pathogenicity locus
toxin
Microbiology
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Acceso en línea:https://doaj.org/article/9c54828146554dea95310db8ae19f8c7
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