Structure of the mouse TRPC4 ion channel

Members of the transient receptor potential (TRP) ion channels conduct cations into cells upon activation by a variety of signals. Here authors present the cryo-EM structure of TRPC4 in its unliganded (apo) state, which provides molecular insights into TRPC4's ion selectivity and TPR channel ev...

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Autores principales:	Jingjing Duan, Jian Li, Bo Zeng, Gui-Lan Chen, Xiaogang Peng, Yixing Zhang, Jianbin Wang, David E. Clapham, Zongli Li, Jin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c5a010f81284360ab0c64e03f609b82
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spelling	oai:doaj.org-article:9c5a010f81284360ab0c64e03f609b822021-12-02T17:31:14ZStructure of the mouse TRPC4 ion channel10.1038/s41467-018-05247-92041-1723https://doaj.org/article/9c5a010f81284360ab0c64e03f609b822018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05247-9https://doaj.org/toc/2041-1723Members of the transient receptor potential (TRP) ion channels conduct cations into cells upon activation by a variety of signals. Here authors present the cryo-EM structure of TRPC4 in its unliganded (apo) state, which provides molecular insights into TRPC4's ion selectivity and TPR channel evolution.Jingjing DuanJian LiBo ZengGui-Lan ChenXiaogang PengYixing ZhangJianbin WangDavid E. ClaphamZongli LiJin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Duan Jian Li Bo Zeng Gui-Lan Chen Xiaogang Peng Yixing Zhang Jianbin Wang David E. Clapham Zongli Li Jin Zhang Structure of the mouse TRPC4 ion channel
description	Members of the transient receptor potential (TRP) ion channels conduct cations into cells upon activation by a variety of signals. Here authors present the cryo-EM structure of TRPC4 in its unliganded (apo) state, which provides molecular insights into TRPC4's ion selectivity and TPR channel evolution.
format	article
author	Jingjing Duan Jian Li Bo Zeng Gui-Lan Chen Xiaogang Peng Yixing Zhang Jianbin Wang David E. Clapham Zongli Li Jin Zhang
author_facet	Jingjing Duan Jian Li Bo Zeng Gui-Lan Chen Xiaogang Peng Yixing Zhang Jianbin Wang David E. Clapham Zongli Li Jin Zhang
author_sort	Jingjing Duan
title	Structure of the mouse TRPC4 ion channel
title_short	Structure of the mouse TRPC4 ion channel
title_full	Structure of the mouse TRPC4 ion channel
title_fullStr	Structure of the mouse TRPC4 ion channel
title_full_unstemmed	Structure of the mouse TRPC4 ion channel
title_sort	structure of the mouse trpc4 ion channel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c5a010f81284360ab0c64e03f609b82
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_version_	1718380687998844928

Structure of the mouse TRPC4 ion channel

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