Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for c...
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KeAi Communications Co., Ltd.
2021
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oai:doaj.org-article:9c5bb91df87e49068053b5a2e622961e2021-12-02T05:02:14ZTwo novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum2405-805X10.1016/j.synbio.2021.10.001https://doaj.org/article/9c5bb91df87e49068053b5a2e622961e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405805X21000648https://doaj.org/toc/2405-805XPhytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1–3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM).Wanying LuGuoliang ZhuWeize YuanZhaoxi HanHuanqin DaiMostafa BasionyLixin ZhangXueting LiuTom HsiangJingyu ZhangKeAi Communications Co., Ltd.articlePathogenic fungusAliphatic unsaturated alcoholsAntibacterialNatural productsBiotechnologyTP248.13-248.65Biology (General)QH301-705.5ENSynthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 446-451 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Pathogenic fungus Aliphatic unsaturated alcohols Antibacterial Natural products Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 |
| spellingShingle |
Pathogenic fungus Aliphatic unsaturated alcohols Antibacterial Natural products Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Wanying Lu Guoliang Zhu Weize Yuan Zhaoxi Han Huanqin Dai Mostafa Basiony Lixin Zhang Xueting Liu Tom Hsiang Jingyu Zhang Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| description |
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1–3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM). |
| format |
article |
| author |
Wanying Lu Guoliang Zhu Weize Yuan Zhaoxi Han Huanqin Dai Mostafa Basiony Lixin Zhang Xueting Liu Tom Hsiang Jingyu Zhang |
| author_facet |
Wanying Lu Guoliang Zhu Weize Yuan Zhaoxi Han Huanqin Dai Mostafa Basiony Lixin Zhang Xueting Liu Tom Hsiang Jingyu Zhang |
| author_sort |
Wanying Lu |
| title |
Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| title_short |
Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| title_full |
Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| title_fullStr |
Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| title_full_unstemmed |
Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum |
| title_sort |
two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus fusarium proliferatum |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9c5bb91df87e49068053b5a2e622961e |
| work_keys_str_mv |
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