Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C
Abstract The MRE11–RAD50–NBS1 (MRN) protein complex plays a vital role in DNA double strand break sensing, signaling, and repair. Mutation in any component of this complex may lead to disease as disrupting DNA double strand break repair has the potential to cause translocations and loss of genomic i...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9c5f84c227e2485fb31d59920f849eb5 |
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