Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators

Abstract While exposure to nicotine during developmental periods can significantly affect brain development, studies examining the association between maternal smoking and autism spectrum disorder (ASD) in offspring have produced conflicting findings, and prior meta-analyses have found no significan...

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Autores principales:	Yonwoo Jung, Angela M. Lee, Sherry A. McKee, Marina R. Picciotto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c60e775136245069ec4c695fbdd24f0
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spelling	oai:doaj.org-article:9c60e775136245069ec4c695fbdd24f02021-12-02T11:52:35ZMaternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators10.1038/s41598-017-04413-12045-2322https://doaj.org/article/9c60e775136245069ec4c695fbdd24f02017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04413-1https://doaj.org/toc/2045-2322Abstract While exposure to nicotine during developmental periods can significantly affect brain development, studies examining the association between maternal smoking and autism spectrum disorder (ASD) in offspring have produced conflicting findings, and prior meta-analyses have found no significant association. Our meta-analysis used a novel approach of investigating population-level smoking metrics as moderators. The main meta-analysis, with 22 observational studies comprising 795,632 cases and 1,829,256 control participants, used a random-effects model to find no significant association between maternal smoking during pregnancy and ASD in offspring (pooled odds ratio (OR) = 1.16, 95% CI: 0.97–1.40). However, meta-regression analyses with moderators were significant when we matched pooled ORs with adult male smoking prevalence (z = 2.55, p = 0.01) in each country, using World Health Organization data. Our study shows that using population-level smoking metrics uncovers significant relationships between maternal smoking and ASD risk. Correlational analyses show that male smoking prevalence approximates secondhand smoke exposure. While we cannot exclude the possibility that our findings reflect the role of paternal or postnatal nicotine exposure, as opposed to maternal or in utero nicotine exposure, this study underlines the importance of investigating paternal and secondhand smoking in addition to maternal smoking in ASD.Yonwoo JungAngela M. LeeSherry A. McKeeMarina R. PicciottoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yonwoo Jung Angela M. Lee Sherry A. McKee Marina R. Picciotto Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
description	Abstract While exposure to nicotine during developmental periods can significantly affect brain development, studies examining the association between maternal smoking and autism spectrum disorder (ASD) in offspring have produced conflicting findings, and prior meta-analyses have found no significant association. Our meta-analysis used a novel approach of investigating population-level smoking metrics as moderators. The main meta-analysis, with 22 observational studies comprising 795,632 cases and 1,829,256 control participants, used a random-effects model to find no significant association between maternal smoking during pregnancy and ASD in offspring (pooled odds ratio (OR) = 1.16, 95% CI: 0.97–1.40). However, meta-regression analyses with moderators were significant when we matched pooled ORs with adult male smoking prevalence (z = 2.55, p = 0.01) in each country, using World Health Organization data. Our study shows that using population-level smoking metrics uncovers significant relationships between maternal smoking and ASD risk. Correlational analyses show that male smoking prevalence approximates secondhand smoke exposure. While we cannot exclude the possibility that our findings reflect the role of paternal or postnatal nicotine exposure, as opposed to maternal or in utero nicotine exposure, this study underlines the importance of investigating paternal and secondhand smoking in addition to maternal smoking in ASD.
format	article
author	Yonwoo Jung Angela M. Lee Sherry A. McKee Marina R. Picciotto
author_facet	Yonwoo Jung Angela M. Lee Sherry A. McKee Marina R. Picciotto
author_sort	Yonwoo Jung
title	Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
title_short	Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
title_full	Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
title_fullStr	Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
title_full_unstemmed	Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
title_sort	maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c60e775136245069ec4c695fbdd24f0
work_keys_str_mv	AT yonwoojung maternalsmokingandautismspectrumdisordermetaanalysiswithpopulationsmokingmetricsasmoderators AT angelamlee maternalsmokingandautismspectrumdisordermetaanalysiswithpopulationsmokingmetricsasmoderators AT sherryamckee maternalsmokingandautismspectrumdisordermetaanalysiswithpopulationsmokingmetricsasmoderators AT marinarpicciotto maternalsmokingandautismspectrumdisordermetaanalysiswithpopulationsmokingmetricsasmoderators
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Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators

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