Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new molecular hallmark in this devastating condition.

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Autores principales:	Raphaelle Luisier, Giulia E. Tyzack, Claire E. Hall, Jamie S. Mitchell, Helen Devine, Doaa M. Taha, Bilal Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe, Rickie Patani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c63023a8964420da0433bba1c3207ac
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spelling	oai:doaj.org-article:9c63023a8964420da0433bba1c3207ac2021-12-02T15:33:34ZIntron retention and nuclear loss of SFPQ are molecular hallmarks of ALS10.1038/s41467-018-04373-82041-1723https://doaj.org/article/9c63023a8964420da0433bba1c3207ac2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04373-8https://doaj.org/toc/2041-1723Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new molecular hallmark in this devastating condition.Raphaelle LuisierGiulia E. TyzackClaire E. HallJamie S. MitchellHelen DevineDoaa M. TahaBilal MalikIone MeyerLinda GreensmithJia NewcombeJernej UleNicholas M. LuscombeRickie PataniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphaelle Luisier Giulia E. Tyzack Claire E. Hall Jamie S. Mitchell Helen Devine Doaa M. Taha Bilal Malik Ione Meyer Linda Greensmith Jia Newcombe Jernej Ule Nicholas M. Luscombe Rickie Patani Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
description	Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new molecular hallmark in this devastating condition.
format	article
author	Raphaelle Luisier Giulia E. Tyzack Claire E. Hall Jamie S. Mitchell Helen Devine Doaa M. Taha Bilal Malik Ione Meyer Linda Greensmith Jia Newcombe Jernej Ule Nicholas M. Luscombe Rickie Patani
author_facet	Raphaelle Luisier Giulia E. Tyzack Claire E. Hall Jamie S. Mitchell Helen Devine Doaa M. Taha Bilal Malik Ione Meyer Linda Greensmith Jia Newcombe Jernej Ule Nicholas M. Luscombe Rickie Patani
author_sort	Raphaelle Luisier
title	Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
title_short	Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
title_full	Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
title_fullStr	Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
title_full_unstemmed	Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
title_sort	intron retention and nuclear loss of sfpq are molecular hallmarks of als
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c63023a8964420da0433bba1c3207ac
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Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

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