Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Abstract Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional conne...

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Autores principales:	Ying Wang, Junjing Wang, Yanbin Jia, Shuming Zhong, Meiqi Niu, Yao Sun, Zhangzhang Qi, Ling Zhao, Li Huang, Ruiwang Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c65d2ceeb604ba4a5d9031d12c3b143
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spelling	oai:doaj.org-article:9c65d2ceeb604ba4a5d9031d12c3b1432021-12-02T15:18:52ZShared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder10.1038/s41598-017-03777-82045-2322https://doaj.org/article/9c65d2ceeb604ba4a5d9031d12c3b1432017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03777-8https://doaj.org/toc/2045-2322Abstract Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional connectivity underlying BD and MDD have not been directly compared. We collected resting-state fMRI data from 48 BD patients, 48 MDD patients, and 51 healthy subjects. We constructed voxel-wise whole-brain functional networks and computed regional functional connectivity strength (FCS) using graph-theory and further divided the regional FCS into long-range FCS (lFCS) and short-range FCS (sFCS). Relative to the controls, both the BD and MDD patients showed decreased sFCS in the bilateral precuneus. In addition, the BD patients showed increased and the MDD patients showed decreased lFCS and sFCS in the bilateral cerebellum. The BD patients also showed increased lFCS in the right middle temporal gyrus and increased sFCS in the bilateral thalamus compared to either the MDD patients or the controls. These findings suggest that BD and MDD may have some shared as well as a greater number of specific impairments in their functional connectivity patterns, providing new evidence for the pathophysiology of BD and MDD at the large-scale whole brain connectivity level.Ying WangJunjing WangYanbin JiaShuming ZhongMeiqi NiuYao SunZhangzhang QiLing ZhaoLi HuangRuiwang HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Wang Junjing Wang Yanbin Jia Shuming Zhong Meiqi Niu Yao Sun Zhangzhang Qi Ling Zhao Li Huang Ruiwang Huang Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
description	Abstract Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional connectivity underlying BD and MDD have not been directly compared. We collected resting-state fMRI data from 48 BD patients, 48 MDD patients, and 51 healthy subjects. We constructed voxel-wise whole-brain functional networks and computed regional functional connectivity strength (FCS) using graph-theory and further divided the regional FCS into long-range FCS (lFCS) and short-range FCS (sFCS). Relative to the controls, both the BD and MDD patients showed decreased sFCS in the bilateral precuneus. In addition, the BD patients showed increased and the MDD patients showed decreased lFCS and sFCS in the bilateral cerebellum. The BD patients also showed increased lFCS in the right middle temporal gyrus and increased sFCS in the bilateral thalamus compared to either the MDD patients or the controls. These findings suggest that BD and MDD may have some shared as well as a greater number of specific impairments in their functional connectivity patterns, providing new evidence for the pathophysiology of BD and MDD at the large-scale whole brain connectivity level.
format	article
author	Ying Wang Junjing Wang Yanbin Jia Shuming Zhong Meiqi Niu Yao Sun Zhangzhang Qi Ling Zhao Li Huang Ruiwang Huang
author_facet	Ying Wang Junjing Wang Yanbin Jia Shuming Zhong Meiqi Niu Yao Sun Zhangzhang Qi Ling Zhao Li Huang Ruiwang Huang
author_sort	Ying Wang
title	Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
title_short	Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
title_full	Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
title_fullStr	Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
title_full_unstemmed	Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder
title_sort	shared and specific intrinsic functional connectivity patterns in unmedicated bipolar disorder and major depressive disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c65d2ceeb604ba4a5d9031d12c3b143
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Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

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