Neuroinflammatory responses to traumatic brain injury

Neuroinflammatory responses to traumatic brain injury

Wellingson Silva Paiva,1 Angelica Duarte Correia,2 Suely Kazue Marie2 1Division of Neurological Surgery, 2Laboratory of Medical Investigation 15, Department of Neurology, University of São Paulo Medical School, Sao Paulo, Brazil We read with great interest the recent study by L...

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Autores principales: Paiva WS, Correia AD, Marie SK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/9c65e1f1efd0472f96ca0e2c7c39ca1f
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spelling oai:doaj.org-article:9c65e1f1efd0472f96ca0e2c7c39ca1f2021-12-02T02:55:18ZNeuroinflammatory responses to traumatic brain injury1178-2021https://doaj.org/article/9c65e1f1efd0472f96ca0e2c7c39ca1f2015-03-01T00:00:00Zhttp://www.dovepress.com/neuroinflammatory-responses-to-traumatic-brainnbspinjury-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Wellingson Silva Paiva,1 Angelica Duarte Correia,2 Suely Kazue Marie2 1Division of Neurological Surgery, 2Laboratory of Medical Investigation 15, Department of Neurology, University of São Paulo Medical School, Sao Paulo, Brazil We read with great interest the recent study by Lozano et al1 published in the Neuropsychiatric Disease and Treatment. The recovery after traumatic brain injury (TBI) is related to severity of the initial injury (primary injury) and the presence of secondary injury.2 Evidences suggest that inflammation, oxidative stress, excitotoxicity, apoptosis, and neuroendocrine responses play an important role in the development of secondary brain injury.3 Therefore, an important part in the management of patients with TBI is trying to minimize the occurrence of deleterious secondary lesions. Lozano et al’s1 paper focused on the role of neuroinflammation in brain injury.Although some studies have described experimental drugs which may eventually have neuroprotective effects in patients with TBI,2–4 there is currently no approved pharmacological treatment for neuroinflammatory effects of the acute phase of the injury. The dissociation between experimental data with positive results and consecutive clinical trials with negative results leads to a dilemma for the treatment of patients with TBI. And, we agree with Lozano et al1 that further clarification of the neuroinflammatory mechanisms could be the basis for addressing the gap between bench and clinical results to provide better treatment and reduce death and sequelae of TBI.View original paper by Lozano and colleagues.Paiva WSCorreia ADMarie SKDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 773-776 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Paiva WS
Correia AD
Marie SK
Neuroinflammatory responses to traumatic brain injury
description Wellingson Silva Paiva,1 Angelica Duarte Correia,2 Suely Kazue Marie2 1Division of Neurological Surgery, 2Laboratory of Medical Investigation 15, Department of Neurology, University of São Paulo Medical School, Sao Paulo, Brazil We read with great interest the recent study by Lozano et al1 published in the Neuropsychiatric Disease and Treatment. The recovery after traumatic brain injury (TBI) is related to severity of the initial injury (primary injury) and the presence of secondary injury.2 Evidences suggest that inflammation, oxidative stress, excitotoxicity, apoptosis, and neuroendocrine responses play an important role in the development of secondary brain injury.3 Therefore, an important part in the management of patients with TBI is trying to minimize the occurrence of deleterious secondary lesions. Lozano et al’s1 paper focused on the role of neuroinflammation in brain injury.Although some studies have described experimental drugs which may eventually have neuroprotective effects in patients with TBI,2–4 there is currently no approved pharmacological treatment for neuroinflammatory effects of the acute phase of the injury. The dissociation between experimental data with positive results and consecutive clinical trials with negative results leads to a dilemma for the treatment of patients with TBI. And, we agree with Lozano et al1 that further clarification of the neuroinflammatory mechanisms could be the basis for addressing the gap between bench and clinical results to provide better treatment and reduce death and sequelae of TBI.View original paper by Lozano and colleagues.
format article
author Paiva WS
Correia AD
Marie SK
author_facet Paiva WS
Correia AD
Marie SK
author_sort Paiva WS
title Neuroinflammatory responses to traumatic brain injury
title_short Neuroinflammatory responses to traumatic brain injury
title_full Neuroinflammatory responses to traumatic brain injury
title_fullStr Neuroinflammatory responses to traumatic brain injury
title_full_unstemmed Neuroinflammatory responses to traumatic brain injury
title_sort neuroinflammatory responses to traumatic brain injury
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/9c65e1f1efd0472f96ca0e2c7c39ca1f
work_keys_str_mv AT paivaws neuroinflammatoryresponsestotraumaticbrainnbspinjury
AT correiaad neuroinflammatoryresponsestotraumaticbrainnbspinjury
AT mariesk neuroinflammatoryresponsestotraumaticbrainnbspinjury
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