Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.

Myopia is increasing worldwide hence it exists a pressing demand to find effective myopia control strategies. Previous studies have shown that light, spectral composition, spatial frequencies, and contrasts play a critical role in refractive development. The effects of light on multiple retinal proc...

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Autores principales:	Antonia Neumann, Katharina Breher, Siegfried Wahl
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c660fa9f3ab4ef392d54dd52122816a
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spelling	oai:doaj.org-article:9c660fa9f3ab4ef392d54dd52122816a2021-12-02T20:08:58ZEffects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.1932-620310.1371/journal.pone.0254877https://doaj.org/article/9c660fa9f3ab4ef392d54dd52122816a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254877https://doaj.org/toc/1932-6203Myopia is increasing worldwide hence it exists a pressing demand to find effective myopia control strategies. Previous studies have shown that light, spectral composition, spatial frequencies, and contrasts play a critical role in refractive development. The effects of light on multiple retinal processes include growth regulation, but also visual performance and perception. Changes in subjective visual performance can be examined by contrast sensitivity (CS). This study was conducted to investigate whether retinal light stimulation of different wavelength ranges is able to elicit changes in CS and, therefore, may be used for myopia control purposes. In total, 30 right eyes were stimulated with the light of different wavelength ranges, including dominant wavelengths of ∼480 nm, ∼530 nm, ∼630 nm and polychromatic light via a commercial liquid crystal display (LCD) screen. Stimulation was performed screen full-field and on the optic nerve head only. CS was measured before any stimulation and after each stimulation condition using a novel and time-efficient CS test. Post-stimulation CS changes were analyzed by ANOVA regarding the influencing factors spatial frequency, stimulation wavelength and stimulation location. A priorly conducted verification study on a subset of five participants compared the newly developed CS test to a validated CS test. The novel CS test exhibited good reliability of 0.94 logCS and repeatability of 0.13 logCS with a duration of 92 sec ± 17 sec. No clinically critical change between pre- and post-stimulation CS was detected (all p>0.05). However, the results showed that post-stimulation CS differed significantly at 18 cpd after stimulation with polychromatic light from short-wavelength light (p<0.0001). Location of illumination (screen full-field vs. optic nerve head) or any interactions with other factors did not reveal significant influences (all p>0.05). To summarize, a novel CS test measures the relationship between retinal light stimulation and CS. However, using retinal illumination via LCD screens to increase CS is inconclusive.Antonia NeumannKatharina BreherSiegfried WahlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254877 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonia Neumann Katharina Breher Siegfried Wahl Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
description	Myopia is increasing worldwide hence it exists a pressing demand to find effective myopia control strategies. Previous studies have shown that light, spectral composition, spatial frequencies, and contrasts play a critical role in refractive development. The effects of light on multiple retinal processes include growth regulation, but also visual performance and perception. Changes in subjective visual performance can be examined by contrast sensitivity (CS). This study was conducted to investigate whether retinal light stimulation of different wavelength ranges is able to elicit changes in CS and, therefore, may be used for myopia control purposes. In total, 30 right eyes were stimulated with the light of different wavelength ranges, including dominant wavelengths of ∼480 nm, ∼530 nm, ∼630 nm and polychromatic light via a commercial liquid crystal display (LCD) screen. Stimulation was performed screen full-field and on the optic nerve head only. CS was measured before any stimulation and after each stimulation condition using a novel and time-efficient CS test. Post-stimulation CS changes were analyzed by ANOVA regarding the influencing factors spatial frequency, stimulation wavelength and stimulation location. A priorly conducted verification study on a subset of five participants compared the newly developed CS test to a validated CS test. The novel CS test exhibited good reliability of 0.94 logCS and repeatability of 0.13 logCS with a duration of 92 sec ± 17 sec. No clinically critical change between pre- and post-stimulation CS was detected (all p>0.05). However, the results showed that post-stimulation CS differed significantly at 18 cpd after stimulation with polychromatic light from short-wavelength light (p<0.0001). Location of illumination (screen full-field vs. optic nerve head) or any interactions with other factors did not reveal significant influences (all p>0.05). To summarize, a novel CS test measures the relationship between retinal light stimulation and CS. However, using retinal illumination via LCD screens to increase CS is inconclusive.
format	article
author	Antonia Neumann Katharina Breher Siegfried Wahl
author_facet	Antonia Neumann Katharina Breher Siegfried Wahl
author_sort	Antonia Neumann
title	Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
title_short	Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
title_full	Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
title_fullStr	Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
title_full_unstemmed	Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
title_sort	effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9c660fa9f3ab4ef392d54dd52122816a
work_keys_str_mv	AT antonianeumann effectsofscreenbasedretinallightstimulationmeasuredwithanovelcontrastsensitivitytest AT katharinabreher effectsofscreenbasedretinallightstimulationmeasuredwithanovelcontrastsensitivitytest AT siegfriedwahl effectsofscreenbasedretinallightstimulationmeasuredwithanovelcontrastsensitivitytest
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Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.

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