SALM4 negatively regulates NMDA receptor function and fear memory consolidation

To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They de...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eunkyung Lie, Yeji Yeo, Eun-Jae Lee, Wangyong Shin, Kyungdeok Kim, Kyung Ah Han, Esther Yang, Tae-Yong Choi, Mihyun Bae, Suho Lee, Seung Min Um, Se-Young Choi, Hyun Kim, Jaewon Ko, Eunjoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9c6821f43b5b415bb8a595e34ac8759f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c6821f43b5b415bb8a595e34ac8759f
record_format	dspace
spelling	oai:doaj.org-article:9c6821f43b5b415bb8a595e34ac8759f2021-12-02T19:16:53ZSALM4 negatively regulates NMDA receptor function and fear memory consolidation10.1038/s42003-021-02656-32399-3642https://doaj.org/article/9c6821f43b5b415bb8a595e34ac8759f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02656-3https://doaj.org/toc/2399-3642To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation.Eunkyung LieYeji YeoEun-Jae LeeWangyong ShinKyungdeok KimKyung Ah HanEsther YangTae-Yong ChoiMihyun BaeSuho LeeSeung Min UmSe-Young ChoiHyun KimJaewon KoEunjoon KimNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eunkyung Lie Yeji Yeo Eun-Jae Lee Wangyong Shin Kyungdeok Kim Kyung Ah Han Esther Yang Tae-Yong Choi Mihyun Bae Suho Lee Seung Min Um Se-Young Choi Hyun Kim Jaewon Ko Eunjoon Kim SALM4 negatively regulates NMDA receptor function and fear memory consolidation
description	To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation.
format	article
author	Eunkyung Lie Yeji Yeo Eun-Jae Lee Wangyong Shin Kyungdeok Kim Kyung Ah Han Esther Yang Tae-Yong Choi Mihyun Bae Suho Lee Seung Min Um Se-Young Choi Hyun Kim Jaewon Ko Eunjoon Kim
author_facet	Eunkyung Lie Yeji Yeo Eun-Jae Lee Wangyong Shin Kyungdeok Kim Kyung Ah Han Esther Yang Tae-Yong Choi Mihyun Bae Suho Lee Seung Min Um Se-Young Choi Hyun Kim Jaewon Ko Eunjoon Kim
author_sort	Eunkyung Lie
title	SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_short	SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_full	SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_fullStr	SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_full_unstemmed	SALM4 negatively regulates NMDA receptor function and fear memory consolidation
title_sort	salm4 negatively regulates nmda receptor function and fear memory consolidation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c6821f43b5b415bb8a595e34ac8759f
work_keys_str_mv	AT eunkyunglie salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT yejiyeo salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT eunjaelee salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT wangyongshin salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT kyungdeokkim salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT kyungahhan salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT estheryang salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT taeyongchoi salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT mihyunbae salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT suholee salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT seungminum salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT seyoungchoi salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT hyunkim salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT jaewonko salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation AT eunjoonkim salm4negativelyregulatesnmdareceptorfunctionandfearmemoryconsolidation
_version_	1718376928887439360

SALM4 negatively regulates NMDA receptor function and fear memory consolidation

Ejemplares similares