Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance

Processing bodies are phase separated compartments enriched in translationally repressed mRNAs. Here, Smith et al. show that, in sensory neurons, eukaryotic elongation factor 2 kinase (eEF2K) plays key roles in the regulation of processing body abundance and the formation of translationally inactive...

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Autores principales: Patrick R. Smith, Sarah Loerch, Nikesh Kunder, Alexander D. Stanowick, Tzu-Fang Lou, Zachary T. Campbell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9c6a9fbaa8f14bc3a227f43bf19fed84
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Sumario:Processing bodies are phase separated compartments enriched in translationally repressed mRNAs. Here, Smith et al. show that, in sensory neurons, eukaryotic elongation factor 2 kinase (eEF2K) plays key roles in the regulation of processing body abundance and the formation of translationally inactive ribosomes.